mProX™ Human SRC Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

In the field of cancer research, SRC inhibitors are being explored as potential antiproliferative agents and kinase inhibitors. Researchers are designing compounds with specific substitutions to target oncogenic kinases and avoid off-target effects. These compounds have shown inhibitory activity against cancer cells and have been found to affect members of the Src family of kinases. Some researchers suggest that small structural changes can have a significant impact on the kinome profile. SRC has been found to play a role in telomere maintenance in stem cells. Fyn, a member of the Src family kinase, has been identified as a kinase that phosphorylates the scaffold protein Menin, leading to disruption of telomere maintenance. This research provides insights into the regulation of telomerase and its potential implications in stem cell function and diseases associated with telomere dysfunction. In the field of lung cancer research, SRC-mediated epithelial-mesenchymal transition (EMT) has been investigated. The root extract of Trichosanthes kirilowii has been found to suppress the metastatic activity of EGFR TKI-resistant lung cancer cells by inhibiting Src-mediated EMT.