mProX™ Human SRC Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Kinase Cell Lines
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Published Data
Fig.1 Cell growth inhibition is observed upon the administration of SRC siRNA.
Untreated or SRC siRNA-transfected MDA-MB-435S cells were subjected to subsequent procedures. After 24 hours, a portion of these cells was allocated for plating into either soft agar or tissue culture dishes. The cells cultivated in soft agar were allowed to proliferate for a duration of 14 days, during which the quantification of colonies was conducted, revealing statistically significant distinctions (*; p<0.05).
Ref: Bjorge, Jeffrey D., et al. "Simultaneous siRNA targeting of Src and downstream signaling molecules inhibit tumor formation and metastasis of a human model breast cancer cell line." PLoS One 6.4 (2011): e19309.
Pubmed: 21541295
DOI: 10.1371/journal.pone.0019309
Research Highlights
Park, Hyun-Ji; Pa, Shin-Hyung. "Root Extract of Trichosanthes kirilowii Suppresses Metastatic Activity of EGFR TKI-Resistant Human Lung Cancer Cells by Inhibiting Src-Mediated EMT." Nutrition and cancer, 2023.
The authors studied how an extract of Trichosanthes kirilowii (TK), a traditional oriental medicine, can inhibit the spread of lung cancer cells that are resistant to drugs targeting EGFR. They found that the extract (ETK) reduced the migration and invasion of resistant cells by reversing the epithelial-mesenchymal transition (EMT), a process that makes cancer cells more aggressive and mobile. They also discovered that ETK deactivates a protein called Src, which regulates EMT, and that a compound called CuB in ETK is responsible for this effect.
Park, Hyun-Ji; Pa, Shin-Hyung. "Root Extract of Trichosanthes kirilowii Suppresses Metastatic Activity of EGFR TKI-Resistant Human Lung Cancer Cells by Inhibiting Src-Mediated EMT." Nutrition and cancer, 2023.
Pubmed:
37870977
DOI:
10.1080/01635581.2023.2272345
B Tabor, Jason. et al. "Use of Biostatistical Models to Manage Replicate Error in Concussion Biomarker Research." JAMA network open, 2023.
Recent research has focused on the investigation of fluid biomarkers associated with sport-related concussion (SRC), with a particular emphasis on detecting low concentrations utilizing ultrasensitive platforms. Nonetheless, conventional statistical methods may fail to take into account potential errors in replicates and exclusion of certain specimens, underscoring the necessity of exploring reliable modeling approaches that take into account all replicate data for a thorough understanding of sample variability and statistical conclusions.
B Tabor, Jason. et al. "Use of Biostatistical Models to Manage Replicate Error in Concussion Biomarker Research." JAMA network open, 2023.
Pubmed:
37870831
DOI:
10.1001/jamanetworkopen.2023.39733
