mProX™ Human SPHK1 Stable Cell Line

[CAT#: S01YF-1023-PY101]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1222-KX490	Magic™ Human SPHK1 in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;SW480;HCT116

Target Classification

Kinase Cell Lines

Target Research Area

Cancer Research

Related Diseases

Renal Fibrosis; Glioblastoma

Gene ID

Human:8877

UniProt ID

Human:Q9NYA1

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

SPHK1 (sphingosine kinase-1) has various applications in different fields. In the field of prostate cancer, a study constructed a prognostic risk model based on inflammation-related genes, including SPHK1, to predict the prognosis of prostate cancer patients. Another study found that SPHK1 is involved in radiation lung injury and regulates the formation of neutrophil extracellular traps (NETs) in chronic kidney disease. Additionally, SPHK1 is also implicated in the protective effect of modified siwu decoction against hypobaric hypoxia and in mediating follicle-stimulating hormone (FSH)-induced cell viability in bovine granulosa cells. These studies highlight the diverse roles of SPHK1 in cancer, lung injury, kidney disease, hypoxia, and reproductive health.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Cameron Davis (Verified Customer)

How does SPHK1 affect inflammation in colitis? Aug 30 2020

chat Patrick Liam (Creative Biolabs Scientific Support)

SPHK1 is targeted by Atractylenolide-1 to regulate intestinal metabolism and flora composition, thereby improving inflammation in colitis. Aug 30 2020

chat Taylor Jones (Verified Customer)

What is the role of SPHK1 in endothelial cell angiogenesis following ischemic stress? Jul 31 2020

chat Patrick Liam (Creative Biolabs Scientific Support)

SPHK1-dependent endothelial cell angiogenesis is regulated by ALKBH5 following ischemic stress. Jul 31 2020

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