mProX™ Human SLK Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Kinase Cell Lines
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Patrick Liam (Creative Biolabs Scientific Support)
Casey Jones (Verified Customer)
Patrick Liam (Creative Biolabs Scientific Support)
Published Data
Fig.1 Invasion of NeuNT-expressing cells is hindered by the knockdown of SLK.
In the chemotaxis assays, NMuMG cells, either expressing NeuNT or the signaling-deficient mutant NYPD, were transfected with SLK siRNA or a non-targeting control. A notable decrease in chemotaxis was detected following SLK depletion.
Ref: Roovers, K., et al. "The Ste20-like kinase SLK is required for ErbB2-driven breast cancer cell motility." Oncogene 28.31 (2009): 2839-2848.
Pubmed: 19525980
DOI: 10.1038/onc.2009.146
Research Highlights
Tang, Jianing. et al. "Targeting USP8 Inhibits O-GlcNAcylation of SLC7A11 to Promote Ferroptosis of Hepatocellular Carcinoma via Stabilization of OGT." Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023.
Hepatocellular carcinoma (HCC) is a highly deadly and aggressive form of cancer in humans. In a recent study, the potential of deubiquitylating enzyme (DUB) inhibitors in treating HCC was investigated. The results showed that targeting ubiquitin specific peptidase 8 (USP8) and using DUB-IN-3 had the most promising anti-cancer effects. Specifically, inhibiting USP8 led to reduced HCC cell proliferation and increased cell ferroptosis. In vivo experiments also showed that USP8 inhibition suppressed tumor growth and lung metastasis. Mechanistic analyses further revealed that USP8 stabilizes O-GlcNAc transferase (OGT) by preventing its K48-specific poly-ubiquitination at the K117 site. Additionally, STE20-like kinase (SLK)-mediated phosphorylation of USP8 at S716 was found to facilitate its interaction with OGT. Notably, it was also discovered that OGT O-GlcNAcylation of solute carrier family 7, member 11 (SLC7A11) at Ser26 is crucial for SLC7A11 to import cystine from the extracellular environment. These findings suggest that targeting USP8 may be a viable option for HCC treatment, as it disrupts the stability of OGT and promotes ferroptosis.
Tang, Jianing. et al. "Targeting USP8 Inhibits O-GlcNAcylation of SLC7A11 to Promote Ferroptosis of Hepatocellular Carcinoma via Stabilization of OGT." Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023.
Pubmed:
37867237
DOI:
10.1002/advs.202302953
Nakajima Doi, Seiko. et al. "Diabetes and Implantable Cardioverter Defibrillator in Nonischemic Systolic Heart Failure: An Extended Follow-Up Analysis of DANISH." Circulation. Heart failure, 2023.
This article is about a study that investigated the effect of diabetes and implantable cardioverter defibrillator (ICD) on the outcomes of patients with nonischemic systolic heart failure. The study was an extended follow-up analysis of DANISH, a randomized clinical trial that compared ICD with usual care.
Nakajima Doi, Seiko. et al. "Diabetes and Implantable Cardioverter Defibrillator in Nonischemic Systolic Heart Failure: An Extended Follow-Up Analysis of DANISH." Circulation. Heart failure, 2023.
Pubmed:
37753706
DOI:
10.1161/CIRCHEARTFAILURE.123.010606
