Recommended
Membrane Protein Drug Discovery In Vitro Assays Membrane Protein In Vitro Assay Kits Membrane Protein Stable Cell Lines Membranes Membrane Protein Virus Particles Membrane Staining and Imaging Reagents
  1. Home
  2. SIRPA
  3. mProX™ Human SIRPA Stable Cell Line
product-img
  • Products
  • Discover MP Targets
  • Discover Research Areas
    • 1- Membrane Protein Stable Cell Line-DiscoverMP Membrane Protein Stable Cell Line, Drug Discovery Tools
    1- Membrane Protein Stable Cell Line-DiscoverMP Other Cell Lines,Drug Discovery Tools

    mProX™ Human SIRPA Stable Cell Line

    [CAT#: S01YF-1023-PY288]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:

    Datasheet MSDS Request COA

    Certificate of Analysis Lookup
    To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
    Lot Number

    Bulk Quote

    Made to Order Inquiry

    Inquiry
    Host Cell Type:
    Membrane Protein Engineering:
    Fluorescent Marker:
    Resistance:
    Deliverable:

    Product Information

    Target Family
    Other Targets
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1;Calu-3
    Target Classification
    Other Targets Drug Discovery Assays and Products
    Target Research Area
    Cancer Research
    Related Diseases
    Glioblastoma; Tenosynovial Giant Cell Tumor
    Gene ID
    Human:140885
    UniProt ID
    Human:P78324

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    SIRPA, or signal regulatory protein alpha, has various applications in different fields. In the context of esophageal carcinoma, high SIRPA expression is associated with poor prognosis and immune infiltrates. In osteosarcoma, SIRPA promotes metastasis by stabilizing SP1 and facilitating arginine uptake. The upregulation of SIRPA in osteosarcoma leads to the formation of an "SP1 stabilization circle" that enhances tumor metastasis. Additionally, SIRPA is involved in immune checkpoint therapy resistance in non-small-cell lung cancer. Inhibition of myeloid-specific KDM6B, an epigenetic enzyme, sensitizes glioblastoma to PD1 blockade by reprogramming immune-suppressive myeloid cells. These findings suggest that targeting SIRPA and its associated pathways may have therapeutic potential in cancer treatment.

    Protocols

    Please visit our protocols page.

    Customer Reviews

    There are currently no Customer reviews or questions for mProX™ Human SIRPA Stable Cell Line (S01YF-1023-PY288). Click the button above to contact us or submit your feedback about this product.

    FAQ

    chat Peyton Jones (Verified Customer)

    What is the role of SIRPA in liver inflammation and fibrosis? May 29 2023

    chat Patrick Liam (Creative Biolabs Scientific Support)

    SIRPA is linked to hepatic inflammation and fibrosis, suggesting that targeting SIRPA has therapeutic potential for chronic fibrotic liver diseases like NAFLD. May 29 2023

    chat Alex Davis (Verified Customer)

    How does SIRPA expression impact prognosis in esophageal carcinoma? Nov 05 2021

    chat Patrick Liam (Creative Biolabs Scientific Support)

    High SIRPA expression in esophageal carcinoma is associated with poor prognosis and correlates with immune infiltrates, indicating its potential as an oncogene and immunotherapy target. Nov 05 2021

    Related Products by Target
    • mProX™ Human SIRPA Stable Cell Line (CAT#: S01YF-1023-PY288)
    • Magic™ Human SIRPA CHO-K1 Cell Line (CAT#: S01YF-0123-KX156)
    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
    Send Inquiry Send Inquiry
    Inquiry Basket
    compare

    Go to compare