mProX™ Human SIK1 Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Kinase Cell Lines
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Published Data
Fig.1 In vitro growth of HCC cell lines was significantly impeded by the robust inhibition exerted by SIK1.
The lower panels display representative images of the entire plate, where the effects of SIK1 on the foci formation assay were assessed.
Ref: Qu, Chao, et al. "Salt-inducible Kinase (SIK1) regulates HCC progression and WNT/β-catenin activation." Journal of hepatology 64.5 (2016): 1076-1089.
Pubmed: 26778753
DOI: 10.1016/j.jhep.2016.01.005
Research Highlights
Taube, Konrad. et al. "Subtle transcriptomic response of Eurasian perch ( Perca fluviatilis) associated with Triaenophorus nodulosus plerocercoid infection" International journal for parasitology. Parasites and wildlife, 2023.
In order to better understand host-parasite interactions and their ecological and evolutionary implications, it is important to investigate the physiological effects of parasites and examine the genes involved in host responses to infections. However, this can be challenging due to the diverse nature and complex life cycles of many parasites. One way to address this issue is through the use of transcriptomics, which can provide qualitative and quantitative data on gene expression patterns in wild-caught specimens. In this study, the authors examined the physiological impact of the pike tapeworm (Triaenophorus nodulosus), a widely distributed parasite.
Taube, Konrad. et al. "Subtle transcriptomic response of Eurasian perch ( Perca fluviatilis) associated with Triaenophorus nodulosus plerocercoid infection" International journal for parasitology. Parasites and wildlife, 2023.
Pubmed:
37869060
DOI:
10.1016/j.ijppaw.2023.09.009
Lopez-Yus, Marta. et al. "CRISPR/Cas9-mediated deletion of adipocyte genes associated with NAFLD alters adipocyte lipid handling and reduces steatosis in hepatocytes in vitro." American journal of physiology. Cell physiology, 2023.
Obesity is a significant contributor to the development of nonalcoholic fatty liver disease (NAFLD). The primary lipid storage depot responsible for regulating lipid movement to other organs is the subcutaneous white adipose tissue (scWAT). Previous research has identified specific genes that are upregulated in the scWAT of individuals with NAFLD. These findings emphasize the crucial role of scWAT in the progression of NAFLD and highlight potential targets for therapeutic interventions.
Lopez-Yus, Marta. et al. "CRISPR/Cas9-mediated deletion of adipocyte genes associated with NAFLD alters adipocyte lipid handling and reduces steatosis in hepatocytes in vitro." American journal of physiology. Cell physiology, 2023.
Pubmed:
37721003
DOI:
10.1152/ajpcell.00291.2023
