mProX™ Human SIK1 Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

SIK1, or salt-inducible kinase 1, has been studied in various contexts and has shown potential applications in different fields. In the context of host-parasite interactions, SIK1 was found to be one of the differentially expressed genes in the spleen and liver of Eurasian perch infected with the pike tapeworm. The study suggests that SIK1 may play a role in the immune response of the host to the parasite. In the field of adipocyte biology, SIK1 was identified as one of the genes upregulated in subcutaneous white adipose tissue (scWAT) of patients with nonalcoholic fatty liver disease (NAFLD). Knockdown of SIK1 in adipocytes altered lipid metabolism and reduced lipid storage in hepatocytes in vitro. This suggests that SIK1 may be involved in the regulation of adipocyte function and could be a potential target for the treatment of NAFLD. In the field of neurobiology, knockdown of SIK3, a related kinase, in the CA1 region of the brain reduced seizure susceptibility in mice by inhibiting decreases in GABA(A)R α1 expression. This indicates that SIK3 may play a role in the development of epilepsy and could be a target for epilepsy treatment. In the field of cancer research, SIK1 was found to suppress colorectal cancer metastasis and chemoresistance via the TGF-β signaling pathway. The study suggests that SIK1 may be a potential therapeutic target for the treatment of colorectal cancer. Overall, SIK1 has shown diverse applications in different biological contexts, including host-parasite interactions, adipocyte biology, neurobiology, and cancer research.