mProX™ Human SGK2 Stable Cell Line

[CAT#: S01YF-1023-PY96]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1222-KX485	Magic™ Human SGK2 in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;HeLa

Target Classification

Kinase Cell Lines

Target Research Area

Cancer Research

Related Diseases

Retinitis Pigmentosa 19; Colorectal Cancer

Gene ID

Human:10110

UniProt ID

Human:Q9HBY8

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

SGK2 (serum glucocorticoid-regulated kinase-2) has various applications in different fields. In the context of ischemia-reperfusion injury, SGK2 has the potential to be therapeutically modulated to reduce the burden of diseases such as myocardial infarction and acute kidney injury. In microvillus inclusion disease, patient-derived enteroids have been used to develop therapeutic approaches, and SGK2 has been identified as a potential pathway involved in rescuing MVID cells. Additionally, SGK2 plays a role in the regulation of epithelial-mesenchymal transition and cancer stem cell phenotypes in hepatocellular carcinoma. Furthermore, a neuroprotective treatment for acute optic neuritis and multiple sclerosis, OCS-05, binds to SGK2, displaying neuroprotective activity. Overall, SGK2 has implications in the development of therapeutic approaches for various diseases and conditions.

Protocols

Please visit our protocols page.

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FAQ

chat Morgan Jones (Verified Customer)

How does SGK2 influence cancer cell behavior? Jan 01 2023

chat Patrick Liam (Creative Biolabs Scientific Support)

SGK2 is involved in regulating the localization and stability of the oncoprotein PTOV1, affecting cell-cycle progression in cancer. Jan 01 2023

chat Casey Johnson (Verified Customer)

What is the role of SGK2 in brown/beige adipose tissue thermogenesis? Dec 16 2021

chat Patrick Liam (Creative Biolabs Scientific Support)

SGK2 is induced by the β3 adrenergic receptor-cAMP-PKA-PGC-1α/NT-PGC-1α axis in brown/beige adipose tissue, although it is dispensable for cold-induced thermogenesis. Dec 16 2021

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