mProX™ Human SGK1 Stable Cell Line

[CAT#: S01YF-1023-PY95]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1222-KX484	Magic™ Human SGK in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;HCT116

Target Classification

Kinase Cell Lines

Target Research Area

Cancer Research

Related Diseases

Gastric Cancer; Pseudohypoaldosteronism

Gene ID

Human:6446

UniProt ID

Human:O00141

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

SGK1 has various applications in different research areas. In liver cancer, miR-3200 affects the transcriptional and translational regulation of several genes, including SGK1, and affects multiple signaling pathways involved in liver cancer growth. In metastatic breast cancer, SGK1-NDRG1 deregulation is associated with ERŒ± loss, and targeting SGK1 may be a potential therapeutic strategy. In dairy cows, SGK1 is involved in the hepatic transcriptome changes related to different serum metabotypes. In C. elegans, SGK-1 is involved in iron homeostasis and its loss-of-function affects lifespan. In buffalo endometrial cells, circulatory extracellular vesicle-derived miR-195-5p promotes cellular apoptosis and suppresses cell proliferation, potentially playing a role in establishing pregnancy. Overall, SGK1 has implications in cancer, metabolism, lifespan, and reproductive biology.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Casey Johnson (Verified Customer)

How does SGK1 contribute to cancer progression? Oct 16 2023

chat Patrick Liam (Creative Biolabs Scientific Support)

SGK1 plays a crucial role in tumorigenesis and cancer progression, making it a potential target for cancer therapy. Oct 16 2023

chat Taylor Smith (Verified Customer)

Can SGK1 inhibition benefit Parkinson's disease models? Feb 09 2020

chat Patrick Liam (Creative Biolabs Scientific Support)

Inhibiting SGK1 in glial cells ameliorates pathologies and symptoms in Parkinson's disease animal models by suppressing inflammatory pathways. Feb 09 2020

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