mProX™ Human RPS6KA4 Stable Cell Line

[CAT#: S01YF-1023-PY14]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1222-KX389	Magic™ Human MSK2(RPS6KA4) in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;HCT116

Target Classification

Kinase Cell Lines

Target Research Area

Pain and Addiction Research

Related Diseases

Coffin-Lowry Syndrome

Gene ID

Human:8986

UniProt ID

Human:O75676

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The RPS6KA4 gene has various applications in different medical fields. In acute myeloid leukemia (AML), a signature constructed based on the RPS6KA4 gene family can be used to predict the prognosis of AML patients and their response to treatment. Additionally, RPS6KA4 may serve as a novel drug target for AML. In hepatocellular carcinoma (HCC), genetic variants in RPS6KA4 are associated with survival rates of HBV-related HCC patients. Higher expression of RPS6KA4 is associated with poor prognosis in HCC patients. Furthermore, RPS6KA4 is implicated in the pathogenesis of HCC and may be involved in epigenetics, cell adhesion, tumor-driven GTPase pathways, and infection-related carcinogenesis. Lastly, RPS6KA4 is also associated with Beh√βet's disease uveitis, where a specific SNP in the NONHSAT159216.1 lncRNA gene, regulated by RPS6KA4, confers susceptibility to the disease.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Casey Smith (Verified Customer)

Is RPS6KA4 overexpression related to any specific cancer types? Jan 18 2022

chat Patrick Liam (Creative Biolabs Scientific Support)

Overexpression of RPS6KA4 is significantly associated with poor prognosis in hepatocellular carcinoma (HCC), including higher T stage, pathological stage, AFP value, and vascular invasion. Jan 18 2022

chat Skyler Jones (Verified Customer)

How does RPS6KA4 overexpression affect survival rates in cancer patients? Apr 08 2023

chat Patrick Liam (Creative Biolabs Scientific Support)

Patients with hepatocellular carcinoma showing RPS6KA4 overexpression have worse overall survival, disease-specific survival, and progress-free interval. Apr 08 2023

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