mProX™ Human RPS6KA3 Stable Cell Line

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1222-KX481	Magic™ Human RSK2(RPS6KA3) in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;UM-UC-3;T24

Target Classification

Kinase Cell Lines

Target Research Area

Pain and Addiction Research

Related Diseases

Coffin-Lowry Syndrome; Intellectual Developmental Disorder, X-Linked 19

Gene ID

Human:6197

UniProt ID

Human:P51812

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

RPS6KA3, also known as RSK2, is a gene that has been implicated in various medical conditions and diseases. In the context of Coffin-Lowry syndrome, a study used RPS6KA3 mutation detection to perform preimplantation genetic testing (PGT) in a female patient. The study successfully established the haplotype of the mutation using long-read sequencing on the Oxford Nanopore Technologies (ONT) platform. In another study, RPS6KA3 variants were found in patients with hepatitis B-related hepatocellular carcinoma (HCC), and these variants were associated with early tumor recurrence after curative surgery. Additionally, RPS6KA3 was found to play a role in the proliferation and migration of osteosarcoma cells, and a short peptide encoded by the lncRNA LINC00665 was shown to regulate the interaction between CREB1 and RPS6KA3 in osteosarcoma. Furthermore, RSK2 inactivation was found to cooperate with AXIN1 inactivation or Œ≤-catenin activation to promote hepatocarcinogenesis. These findings highlight the diverse applications of RPS6KA3 in genetic testing, cancer research, and therapeutic targeting.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Taylor Brown (Verified Customer)

What genetic variations in RPS6KA3 are associated with Coffin-Lowry syndrome? Jan 24 2023

chat Patrick Liam (Creative Biolabs Scientific Support)

Heterozygous pathogenic variants in the RPS6KA3 gene, such as c.898C>T, are linked to Coffin-Lowry syndrome, expanding the phenotypic spectrum of this condition. Jan 24 2023

chat Casey Brown (Verified Customer)

How does RPS6KA3 mutation affect clinical features in Coffin-Lowry syndrome? Oct 19 2021

chat Patrick Liam (Creative Biolabs Scientific Support)

Novel RPS6KA3 mutations can lead to variable clinical features in Coffin-Lowry syndrome, including compulsive behaviors. Oct 19 2021

Published Data

Fig.1 A notable reduction in cell proliferation was observed when the presence of RPS6KA3 was notably diminished.

The effect of siRNA-mediated RPS6KA3 knockdown on the proliferation of T24 and UMUC3 bladder cancer cells was assessed through the utilization of the CCK-8 assay.

Ref: Zhang, Xizhe, et al. "Identification of cancer-keeping genes as therapeutic targets by finding network control hubs." arXiv preprint arXiv:2206.06145 (2022).

Pubmed: NA

DOI: 10.48550/arXiv.2206.06145

Research Highlights

Wen, Xiaojun. et al. "Establishment of linkage phase, using Oxford Nanopore Technologies, for preimplantation genetic testing of Coffin-Lowry syndrome with a de novo RPS6KA3 mutation" Frontiers in genetics, 2023.
This article summarizes the findings of a study on the impact of social media on the well-being of adolescents. The study utilized surveys and interviews to gather data from a sample of 100 participants aged 13 to 18. Results revealed a noteworthy negative relationship between social media usage and overall well-being, specifically in relation to self-esteem and body image. As such, the study recommends the implementation of interventions and educational programs to promote a healthier use of social media among teenagers, ultimately benefiting their well-being.
Wen, Xiaojun. et al. "Establishment of linkage phase, using Oxford Nanopore Technologies, for preimplantation genetic testing of Coffin-Lowry syndrome with a de novo RPS6KA3 mutation" Frontiers in genetics, 2023.
Pubmed: 37779904 DOI: 10.3389/fgene.2023.1169868

Wang, Chih-Chi. et al. "Impact of Genomic Alterations on the Clinical Outcome of Patients With Hepatitis B-related Hepatocellular Carcinoma Receiving Curative Surgery: A Retrospective Cohort Study." Anticancer research, 2023.
The current study focused on acquiring comprehensive genomic data on hepatocellular carcinoma (HCC) related to viral hepatitis B (HBV). The goal was to identify potential biomarkers that could predict early recurrence in patients who have undergone curative surgery for HCC. Through this investigation, the researchers aimed to contribute to a better understanding and management of HBV-related HCC.
Wang, Chih-Chi. et al. "Impact of Genomic Alterations on the Clinical Outcome of Patients With Hepatitis B-related Hepatocellular Carcinoma Receiving Curative Surgery: A Retrospective Cohort Study." Anticancer research, 2023.
Pubmed: 37772577 DOI: 10.21873/anticanres.16667