mProX™ Human ROCK2 Stable Cell Line

[CAT#: S01YF-1023-PY88]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1222-KX477	Magic™ Human ROCK2 in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;SCC-12F

Target Classification

Kinase Cell Lines

Target Research Area

Cancer Research

Related Diseases

Ureteral Obstruction; Breast Cancer

Gene ID

Human:9475

UniProt ID

Human:O75116

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

ROCK2, or Rho-associated coiled-coil kinase 2, has various applications in different fields. In glioma cells, ROCK2 is involved in temozolomide (TMZ) resistance, and its inhibition can enhance the sensitivity of glioma cells to TMZ. In hindlimb ischemia, selective ROCK inhibitors can enhance blood flow recovery by promoting endothelial network formation. In diabetic nephropathy, ROCK2 is part of the ROCK/IKK/NF-Œ∫B pathway and its inhibition can improve renal inflammatory injury. In lymphatics, ROCK2 is responsible for cytokine-induced lymphatic junction tightening, and its inhibition can normalize fluid drainage and reverse lymphedema. In pulmonary arterial hypertension, ROCK2 is identified as an immune-related gene and a potential therapeutic target. These findings highlight the diverse roles of ROCK2 in different biological processes and diseases.

Protocols

Please visit our protocols page.

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FAQ

chat Cameron Brown (Verified Customer)

What is the role of ROCK2 in Alzheimer's disease? Apr 23 2022

chat Patrick Liam (Creative Biolabs Scientific Support)

Inhibition of ROCK2 has been proposed as a potential approach for managing Alzheimer's disease, highlighting its role in neurodegenerative processes. Apr 23 2022

chat Peyton Miller (Verified Customer)

Can ROCK2 be targeted in inflammatory diseases? Aug 09 2023

chat Patrick Liam (Creative Biolabs Scientific Support)

ROCK2 inhibition, as seen with drugs like belumosudil, has shown effectiveness in treating chronic graft-versus-host disease, suggesting its role in inflammatory pathways. Aug 09 2023

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