mProX™ Human RARG Stable Cell Line

[CAT#: S01YF-1123-KX107]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Nuclear Receptor

Certificate of Analysis Lookup
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Lot Number

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Product Information

Target Protein

RARG

Target Family

Retinoic Acid Receptor

Target Protein Species

Human

Host Cell Type

HCC; CHO-K1; HEK293

Target Classification

Nuclear Receptor

Target Research Area

Autoimmune Research; Cancer Research; Inflammation Research

Related Diseases

Embryonal Carcinoma; Exfoliative Ichthyosis

Gene ID

5916

UniProt ID

P13631

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The nuclear receptor known as retinoic acid receptor gamma (RAR-γ) is encoded by the RARG gene. Adapalene specifically targets the retinoic acid receptor beta and retinoic acid receptor gamma; the effects of adapalene are primarily due to its agonism of the gamma subtype. Mice lacking RARγ show growth deficits. Anteriorization of the cervical and thoracic vertebrae is one of the axial skeleton's abnormalities caused by the absence of RARγ, which controls hindbrain and axial patterning. The development of healthy alveoli and alveolar elastic fibers in the lung depends on RARγ. Male sterility is caused by genetic ablation of RARγ, which is also linked to keratinization of glandular epithelia and squamous metaplasia of the prostate gland and seminal vesicles. The customized RARG stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat Carol

I purchased the RARG cell line from Creative Biolabs and the provided documentation was comprehensive and helped me optimize my assay conditions. Mar 09 2023

chat Verified Customer

chat Kevin

I've been using the human RARG cell line for my studies, and it has been an excellent choice. Jan 13 2021

chat Verified Customer

FAQ

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