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    Family stable cell lines Peptide P518 Family Stable Cell Lines; Innovative Tools, Membrane Protein Drug Discovery.

    mProX™ Human QRFPR Stable Cell Line

    [CAT#: S01YF-1023-PY323]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:

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    Product Information

    Target Family
    Peptide P518 Family
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1;Human iPSC-derived neurons
    Target Classification
    Other Targets Drug Discovery Assays and Products
    Gene ID
    Human:84109
    UniProt ID
    Human:Q96P65

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    QRFPR, or the QRFP receptor, has been identified as a G-protein coupled receptor for the neuropeptide QRFP. Recent studies have highlighted its role in regulating appetite, energy homeostasis, and circadian rhythms. Dysregulation of QRFPR signaling has been linked to obesity and metabolic disorders. Moreover, QRFPR has been shown to regulate the intake of dietary fat, suggesting its potential as a therapeutic target for obesity and related metabolic diseases.

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    FAQ

    chat Jessica (Verified Customer)

    How do variations in the human orphan G protein-coupled receptor QRFPR affect cellular signaling pathways? Feb 24 2020

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Variations in QRFPR, specifically the p.Y68H and p.R371 W variations, can reduce the mobilization of intracellular Ca(2+). These variations suggest that QRFPR plays an important role in neurodevelopment, with its effects likely mediated by the Ca(2+)-dependent pathways. Feb 24 2020

    chat Anthony (Verified Customer)

    What is the significance of N-glycosylation in the human neuropeptide QRFP receptor (QRFPR)? Mar 05 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    N-glycosylation of QRFPR is essential for its proper function. Specifically, the human QRFP receptor QRFPR possesses three N-glycosylation consensus sites. Proper glycosylation is crucial for ligand binding and receptor activation. Mar 05 2022

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    • Magic™ Human QRFPR CHO-K1 Cell Line with Aequorin Reporter, Calcium flux assay (CAT#: S01YF-1222-KX228)
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