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  • mProX™ Human PVRIG Stable Cell Line

    [CAT#: S01YF-1023-PY284]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:

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    Product Information

    Target Family
    Other Targets
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1
    Target Classification
    Other Targets Drug Discovery Assays and Products
    Gene ID
    Human:79037
    UniProt ID
    Human:Q6DKI7

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    Recent studies have highlighted the potential applications of PVRIG (CD112R) in various diseases. One study revealed an inverse causal relationship between Alzheimer's disease (AD) and cancer, with PVRIG upregulation identified as a risk factor for AD but a protective factor for cancer. Another study found that elevated CD112R and PD-1 expression levels in cytotoxic T lymphocytes located in T cell nests of colorectal cancer predicted favorable patient outcomes. In hepatocellular carcinoma (HCC), PVRIG expression was an independent prognostic factor and a potential target for immunotherapy. Additionally, the CD226 axis, which includes CD226, TIGIT, CD96, and PVRIG, has been implicated in cancer immunotherapy, with ongoing research on their therapeutic strategies and underlying biology. These findings suggest the potential of targeting PVRIG and the CD226 axis for the treatment of various diseases.

    Protocols

    Please visit our protocols page.

    Customer Reviews

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    FAQ

    chat Morgan Miller (Verified Customer)

    What is the role of PVRIG in tumor immunity? Feb 07 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    PVRIG acts as an inhibitory immune checkpoint in cancer, with its blockade shown to enhance anti-tumor immunity, particularly in NK cells. Feb 07 2022

    chat Peyton Smith (Verified Customer)

    How does PVRIG interact with other immune checkpoints like TIGIT and PD-1? Jul 22 2023

    chat Patrick Liam (Creative Biolabs Scientific Support)

    PVRIG, TIGIT, and PD-1 pathways are non-redundant inhibitory signaling pathways in cancer, with combined blockade of these checkpoints potentially beneficial in cancer therapy. Jul 22 2023
    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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