mProX™ Human PTK2B Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

PTK2B, also known as protein tyrosine kinase 2 beta, is a gene that has been studied in various contexts. In the context of low bone mineral density in postmenopausal women, PTK2B was found to be upregulated in individuals with osteopenia and osteoporosis compared to those with normal bone mineral density. It was identified as a potential candidate biomarker for the early diagnosis of osteoporosis. In the context of polycystic ovary syndrome (PCOS), PTK2B was found to be upregulated in granulosa cells from patients with PCOS compared to controls. It was implicated in the pathogenesis of PCOS and was associated with NLRP3 inflammasome-dependent pathway activation. In the context of lung adenocarcinoma, PTK2B was identified as a hub gene in a prognostic signature. High expression of PTK2B was associated with reduced survival rates and lower levels of immune cell infiltration. In the context of Hashimoto's thyroiditis, PTK2B was identified as a hub gene associated with immune and oxidative stress dysregulation. Its expression was positively correlated with serum antibody levels and inflammatory infiltration scores. Finally, in the context of gastrointestinal nematode infection in sheep, PTK2B was identified as a candidate gene associated with the biological response to infection. These studies highlight the diverse applications of PTK2B in different disease contexts.