mProX™ Human PRKX Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Kinase Cell Lines
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Patrick Liam (Creative Biolabs Scientific Support)
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Patrick Liam (Creative Biolabs Scientific Support)
Published Data
Fig.1 The impact of PRKX overexpression on endothelial cell migration was examined, revealing alterations in migratory behavior.
Cell migration was assessed in HUVECs either devoid of transduction or transduced with three distinct viral constructs, and measurements were made at 4 h, 8 h, 18 h, and 24 h. The data presented here represent the mean ± SE derived from two separate experiments, each consisting of 4 replicates. Significance levels were denoted as *p < 0.05 and **p < 0.01.
Ref: Li, Xiaohong, et al. "PRKX critically regulates endothelial cell proliferation, migration, and vascular-like structure formation." Developmental biology 356.2 (2011): 475-485.
Pubmed: 21684272
DOI: 10.1016/j.ydbio.2011.05.673
Research Highlights
Yang, Xiao et al. "PRKX down-regulates TAK1/IRF7 signaling in the antiviral innate immunity of black carp Mylopharyngodon piceus." Frontiers in immunology vol. 13 999219. 11 Jan. 2023.
In teleost, the relationship between TGF-β-activated kinase-1 (TAK1) and X-linked protein kinase (PRKX) had remained unknown until now. A recent study investigated the interplay between black carp's TAK1 (bcTAK1) and its counterpart bcPRKX. The findings revealed that overexpressed bcPRKX had contrasting effects on interferon and NF-κB promoters. Knocking down bcPRKX in Mylopharyngodon piceus kidney (MPK) cells boosted antiviral activity against SVCV, increasing the expression of antiviral proteins. The study also uncovered that bcPRKX interacted with and triggered the degradation of bcTAK1 through lysosome-dependent pathways, ultimately inhibiting the innate immune response.
Yang, Xiao et al. "PRKX down-regulates TAK1/IRF7 signaling in the antiviral innate immunity of black carp Mylopharyngodon piceus." Frontiers in immunology vol. 13 999219. 11 Jan. 2023.
Pubmed:
36713382
DOI:
10.3389/fimmu.2022.999219
Urbán, Péter, et al. "miRNA profiling of developing rat retina in the first three postnatal weeks." Cellular and Molecular Neurobiology (2023): 1-12.
In this study, the development of the mammalian retina was examined, focusing on the role of small non-coding RNAs, particularly microRNAs, in gene expression regulation. Utilizing the IonTorrent PGM next-generation sequencing technique, a comprehensive analysis of these RNAs in Wistar rat retinas at various postnatal stages (P5, P7, P10, P15, and P21) was conducted. The findings highlight the significant regulatory potential of microRNAs in retinal development, identifying both consistently abundant and stage-specific microRNAs. Additionally, pathway enrichment analysis uncovered 850 predicted target genes involved in various metabolic processes. Critical transitions in retinal development, especially between P5 and P7, were linked to changes in miRNA expression, influencing key pathways in retinal morphogenesis. The study's dataset offers valuable insights into new regulatory mechanisms in retinal development and the diverse functions of microRNAs.
Urbán, Péter, et al. "miRNA profiling of developing rat retina in the first three postnatal weeks." Cellular and Molecular Neurobiology (2023): 1-12.
Pubmed:
37084144
DOI:
10.1007/s10571-023-01347-3
