mProX™ Human PRKD2 Stable Cell Line

[CAT#: S01YF-1023-PY71]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1222-KX451	Magic™ Human PKD2(PRKD2) in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;KASUMI;U937

Target Classification

Kinase Cell Lines

Target Research Area

Cancer Research

Related Diseases

Angiolipoma; Conventional Lipoma

Gene ID

Human:25865

UniProt ID

Human:Q9BZL6

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

PRKD2, a member of the protein kinase D (PKD) family, has been implicated in various diseases, including polymorphous adenocarcinoma (PAC), osteoarthritis (OA), COVID-19 complications, prostate cancer (PCa), and cholangiocarcinoma (CCA). In PAC, PRKD2 gene fusions have been identified, along with novel fusion partners such as ARID1A and ARID1B. In OA, PRKD2 is associated with genetic regulatory effects and potential pathways involved in the disease. In COVID-19 ICU patients, increased levels of autoantibodies related to the male reproductive system, including PRKD2, have been observed. In PCa, PRKD2 is upregulated and may play an oncogenic role, suggesting the potential for PRKD inhibitors in treatment. In CCA, PRKD2, along with PRKD1 and PRKD3, has been identified as a critical regulator, and inhibition of the PKD family, including PRKD2, shows promise as a therapeutic approach. Overall, PRKD2 has diverse applications in different diseases, highlighting its significance as a potential target for diagnosis, treatment, and further research.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Casey Smith (Verified Customer)

What is the role of PRKD2 in cervical cancer chemotherapy sensitivity? Feb 11 2020

chat Patrick Liam (Creative Biolabs Scientific Support)

Knockdown of PRKD2 enhances chemotherapy sensitivity in cervical cancer via the TP53/CDKN1A pathway. Feb 11 2020

chat Jordan Garcia (Verified Customer)

How does PRKD2 influence T follicular helper cell differentiation? Jun 06 2023

chat Patrick Liam (Creative Biolabs Scientific Support)

PRKD2 and Bcl6 form a mutually inhibitory feedback loop controlling the transition from naïve CD4+ T cells to T follicular helper cells. Jun 06 2023

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