mProX™ Human PRKCG Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

PRKCG, which encodes Protein Kinase C gamma (PKCγ), has been implicated in various biological processes and diseases. In a study on late-onset spinocerebellar atrophy type 14, mutations in PKCγ were found to be the cause of the disease. Another study investigated the role of PKCγ in aflatoxin B1 (AFB1)-mediated toxicity in porcine alveolar macrophages (PAM). The study revealed that AFB1 exposure led to the activation of the calcium signaling pathway through the ceRNA regulatory network, involving the competitive binding of specific microRNAs and the upregulation of PKCγ. In the context of postoperative pain, the interaction between NETO2 and GluK2 was found to contribute to pain hypersensitivity by inducing PKCγ activation and the synaptic incorporation of AMPA receptor GluR1 subunits in the rat dorsal horn. Additionally, PKCγ fusion genes were identified in melanocytic neoplasms, suggesting a role for PKCγ in the pathogenesis of these tumors. Finally, a viewpoint article discussed the involvement of PKCγ in spinocerebellar ataxias, proposing that dysfunction of Purkinje cells, rather than their loss, may be the primary driver of these diseases. Overall, these studies highlight the diverse applications of PRKCG in various biological processes and diseases.