mProX™ Human PRKCD Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

PRKCD, also known as protein kinase C delta, has various applications in different fields. In the field of cancer research, a study found that TRIM69, a protein, can suppress the resistance to cell death (anoikis) and metastasis in gastric cancer cells by promoting the degradation of PRKCD through a process called ubiquitin-proteasome-mediated degradation. This suggests that targeting PRKCD could be a potential therapeutic approach for metastatic gastric cancer. Additionally, PRKCD has been implicated in the antioxidant and anti-inflammatory properties of lipophilic extracts from Polyscias fruticosa leaves and Liriope platyphylla seeds. These extracts contain compounds that regulate PRKCD and other target genes involved in oxidative stress and inflammation-related pathways. The antioxidant and anti-inflammatory effects of these extracts make them promising candidates for the development of functional foods and nutraceuticals. Furthermore, PRKCD deficiency has been linked to systemic lupus erythematosus and other autoimmune and immunodeficiency disorders. Understanding the role of PRKCD in immune tolerance and effector functions against pathogens is crucial for the diagnosis and management of these conditions. Overall, PRKCD has diverse applications in cancer research, natural product development, and immunology.