mProX™ Human PRKACG Stable Cell Line

[CAT#: S01YF-1023-PY60]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1222-KX439	Magic™ Human PKACγ(PRKACG) in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;HeLa

Target Classification

Kinase Cell Lines

Target Research Area

Immunology Research

Related Diseases

Bleeding Disorder, Platelet-Type, 19; Stormorken Syndrome

Gene ID

Human:5568

UniProt ID

Human:P22612

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

PRKACG, a gene involved in the cyclic AMP-dependent protein kinase A (PKA) pathway, has been implicated in various diseases and conditions. In coronary artery disease (CAD), the up-regulation of PRKACG is associated with higher levels of high-density lipoprotein cholesterol (HDL-C) and the efficiency of reverse cholesterol transport. In Alzheimer's disease (AD) and type 2 diabetes mellitus (DM), PRKACG is identified as one of the essential hub genes and may play a role in the shared pathophysiological mechanisms of these diseases. In breast cancer, low expression of PKA, which includes PRKACG, is associated with adverse patient survival, particularly in estrogen receptor-positive breast cancer. Overall, PRKACG has been identified as a potential target for the diagnosis and treatment of CAD, AD, DM, and breast cancer.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Skyler Garcia (Verified Customer)

What is the role of PRKACG in platelet biogenesis? Aug 06 2021

chat Patrick Liam (Creative Biolabs Scientific Support)

PRKACG is a central actor in platelet biogenesis, and mutations in this gene can lead to inherited thrombocytopenia with giant platelets. Aug 06 2021

chat Jordan Garcia (Verified Customer)

How is PRKACG linked to coronary artery disease? Aug 29 2021

chat Patrick Liam (Creative Biolabs Scientific Support)

In coronary artery disease, PRKACG expression is a positive predictor of high-density lipoprotein cholesterol levels, impacting HDL functionality. Aug 29 2021

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