mProX™ Human PRKACB Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

PRKACB (protein kinase cAMP-activated catalytic subunit beta) has several applications. In the context of pancreatobiliary oncocytic neoplasms, gene rearrangement and expression of PRKACB play a role in the morpho-biology of these tumors. PRKACB fusion genes are characteristic drivers of intraductal oncocytic papillary neoplasms (IOPNs) and are associated with upregulation of PRKACB and PRKACA, as well as phosphorylated-CREB. PRKACB also has implications in coronary artery disease, where its expression is upregulated in peripheral blood mononuclear cells of patients with CAD. In the context of oligoasthenozoospermia, PRKACB is upregulated in response to treatment with hyperoside, leading to improvements in sperm density and testicular function. Additionally, PRKACB is involved in the mechanism of Moringa oleifera leaf extract in treating constipation, modulating signaling pathways related to gastrointestinal motility and intestinal fluid secretion. Finally, PRKACB is implicated in augmented renal clearance, where its expression is altered along with other genes and metabolites associated with ARC. Overall, PRKACB is involved in various biological processes and may have potential therapeutic implications in different conditions.