mProX™ Human PRKACA Stable Cell Line

[CAT#: S01YF-1023-PY58]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1222-KX437	Magic™ Human PKACα(PRKACA) in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1

Target Classification

Kinase Cell Lines

Target Research Area

Cardiovascular Research

Related Diseases

Cardioacrofacial Dysplasia 1; Pigmented Nodular Adrenocortical Disease, Primary, 4

Gene ID

Human:5566

UniProt ID

Human:P17612

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

PRKACA is a gene that is involved in various biological processes and has implications in different diseases. In pancreatic and biliary neoplasms, PRKACA gene rearrangement and expression play a crucial role in the morpho-biology of oncocytic neoplasms. It is also associated with the development of subclonal oncocytic neoplasms and is strongly associated with oncocytic morphology. In small cell lung cancer, prolonged exposure to environmental concentrations of benzo[a]pyrene (BaP) promotes cancer stemness through the AhR/PKA/SOX2 pathway. Additionally, PRKACA is implicated in the regulation of the cytoskeleton and mitophagy in ischemic cardiomyopathy. Furthermore, PRKACA inhibitors have been discovered and synthesized, which selectively inhibit distinct classes of serine/threonine kinases. These findings provide insights into the role of PRKACA in different biological processes and diseases, and may have implications for potential therapeutic targets.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Casey Johnson (Verified Customer)

Can the DNAJB1-PRKACA fusion protein be targeted in fibrolamellar hepatocellular carcinoma? Mar 05 2020

chat Patrick Liam (Creative Biolabs Scientific Support)

Yes, the DNAJB1-PRKACA fusion protein can be specifically targeted by peptide-based immunotherapy in fibrolamellar hepatocellular carcinoma. Mar 05 2020

chat Taylor Williams (Verified Customer)

Is PRKACA a viable therapeutic target for fibrolamellar carcinoma? Oct 24 2021

chat Patrick Liam (Creative Biolabs Scientific Support)

PRKACA is a viable therapeutic target for fibrolamellar carcinoma, as its inhibition results in cell death and tumor growth cessation. Oct 24 2021

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