mProX™ Human PLK2 Stable Cell Line

[CAT#: S01YF-1023-PY78]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1222-KX458	Magic™ Human PLK2 in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;T98G;A172

Target Classification

Kinase Cell Lines

Target Research Area

Cancer Research

Related Diseases

Hereditary Breast Ovarian Cancer Syndrome; Epilepsy, Familial Temporal Lobe, 2

Gene ID

Human:10769

UniProt ID

Human:Q9NYY3

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

PLK2, or Polo-like kinase 2, has various applications in different fields. In liver cancer, PLK2 is affected by miR-3200, a noncoding RNA, and is involved in the growth of liver cancer cells by enhancing Rab7A. PLK2 also plays a role in synaptic destabilization in the brain, where it disrupts N-cadherin adhesion complexes during homeostatic adaptation to hyperexcitation. Additionally, PLK2 is implicated in the aggregation and cytotoxicity of Œ±-synuclein, a protein associated with neurodegenerative disorders. It phosphorylates Œ±-synuclein at multiple serine residues, leading to increased aggregation potential and toxicity. In non-small cell lung cancer, PLK2 is part of a pathway that can be targeted to overcome acquired resistance to EGFR-TKIs. Finally, PLK2 is involved in the expression of genes regulating cell division in porcine follicular granulosa cells, affecting processes related to ovarian follicular growth and ovulation.

Protocols

Please visit our protocols page.

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FAQ

chat Casey Davis (Verified Customer)

What is the significance of PLK2 in glioblastoma prognosis? Jan 28 2022

chat Patrick Liam (Creative Biolabs Scientific Support)

PLK2 may serve as a novel biomarker for the prognosis of glioblastoma and a potential target for treatment. Jan 28 2022

chat Casey Jones (Verified Customer)

How does PLK2 affect kidney injury? Feb 12 2021

chat Patrick Liam (Creative Biolabs Scientific Support)

PLK2 acts as an anti-oxidative and anti-inflammatory regulator, protecting kidney cells from toxicants and stresses. Feb 12 2021

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