mProX™ Human PKN3 Stable Cell Line

[CAT#: S01YF-1023-PY75]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1222-KX455	Magic™ Human PKN3 in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;PC-3

Target Classification

Kinase Cell Lines

Target Research Area

Ocular Research;CNS Research

Related Diseases

Nonarteritic Anterior Ischemic Optic Neuropathy; Gastrointestinal Neuroendocrine Tumor

Gene ID

Human:29941

UniProt ID

Human:Q6P5Z2

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

PKN3, or protein kinase N3, has various applications in different fields. In the field of reproductive biology, PKN3 has been found to be downregulated in preeclamptic placenta and its upregulation through the inhibition of autophagy promotes trophoblast invasion. In cancer research, PKN3 has been identified as a target in cancer metastasis, particularly in breast cancer and prostate cancer. RNA interference (RNAi) therapy using PKN3-specific shRNA has shown promise in inhibiting tumor growth. Additionally, PKN3 has been implicated in the regulation of different hair types in Inner Mongolia cashmere goats, where the PI3K-AKT pathway and FGF21 are involved. Furthermore, lipid nanoparticles have been developed for the efficient delivery of PKN3 shRNA for the treatment of breast cancer and prostate cancer. Overall, PKN3 plays a role in trophoblast invasion, cancer metastasis, hair type regulation, and can be targeted for therapeutic interventions in cancer.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Cameron Miller (Verified Customer)

How does PKN3 affect breast cancer treatment? Sep 17 2020

chat Patrick Liam (Creative Biolabs Scientific Support)

Efficient delivery of PKN3 shRNA via lipid nanoparticles has been studied for the treatment of breast cancer. Sep 17 2020

chat Cameron Brown (Verified Customer)

What is the role of PKN3 in cancer metastasis? Sep 07 2021

chat Patrick Liam (Creative Biolabs Scientific Support)

PKN3 is a critical regulator in cancer metastasis, and its inhibition may represent a potential therapeutic target. Sep 07 2021

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