mProX™ Human PKN2 Stable Cell Line

[CAT#: S01YF-1023-PY74]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1222-KX454	Magic™ Human PKN2 in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;HCT116

Target Classification

Kinase Cell Lines

Target Research Area

Digestive and Renal Research

Related Diseases

Toe Syndactyly, Telecanthus, And Anogenital And Renal Malformations; Bubonic Plague

Gene ID

Human:5586

UniProt ID

Human:Q16513

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

PKN2, a protein kinase, has been implicated in various biological processes and diseases. In Alzheimer's disease, differential gene co-expression analysis identified PKN2 as one of the genes involved in the pathophysiology of the disease. In another study, PKN2 was found to be an active serine kinase in the bacterium Synechocystis sp. PCC 6803. Additionally, phosphorylation of KRT8 by PKN2 was shown to impair autophagosome initiation and contribute to disc degeneration. In largemouth bass, selective pressure has led to genetic variations in PKN2 and other genes associated with important traits. Finally, in septic mice, the PI3K-Akt signaling pathway, in which PKN2 is involved, was identified as a therapeutic mechanism in the hydrogen-induced alleviation of brain injury. These studies highlight the diverse roles of PKN2 in different biological contexts and diseases.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Alex Brown (Verified Customer)

How does PKN2 inhibition affect cancer cells? Jun 26 2020

chat Patrick Liam (Creative Biolabs Scientific Support)

Inhibiting PKN2 has shown cytotoxic properties in cancer cells, suggesting its potential as a therapeutic target in cancer treatment. Jun 26 2020

chat Peyton Johnson (Verified Customer)

What is the role of PKN2 in cardiomyopathy and stress responses? Jun 29 2022

chat Patrick Liam (Creative Biolabs Scientific Support)

PKN2 is essential for heart development and formation of compact myocardium, and is required for cardiac hypertrophy in hypertension, indicating its importance in both congenital and adult heart diseases. Jun 29 2022

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