mProX™ Human PIM3 Stable Cell Line

[CAT#: S01YF-1023-PY57]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1222-KX436	Magic™ Human PIM3 in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;HuH-6

Target Classification

Kinase Cell Lines

Target Research Area

Cancer Research

Related Diseases

Hepatic Flexure Cancer; Spinocerebellar Ataxia, X-Linked 5

Gene ID

Human:415116

UniProt ID

Human:Q86V86

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

PIM3, a member of the PIM kinase family, has been identified as a crucial player in various cellular processes, including cell survival, proliferation, and differentiation. In the realm of scientific research, PIM3 has garnered attention for its role in tumorigenesis and cancer progression. Specifically, PIM3 has been implicated in the development and progression of hepatocellular carcinoma (HCC), a prevalent and aggressive form of liver cancer. The kinase has been found to promote the survival of HCC cells, making it a potential therapeutic target for the treatment of this malignancy. Furthermore, the overexpression of PIM3 has been associated with poor prognosis in patients with pancreatic ductal adenocarcinoma, suggesting its potential as a prognostic biomarker. The significance of PIM3 in cancer biology underscores the need for further research to elucidate its molecular mechanisms and therapeutic potential.

Protocols

Please visit our protocols page.

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FAQ

chat Casey Davis (Verified Customer)

How does PIM3 influence bladder cancer progression? Feb 17 2021

chat Patrick Liam (Creative Biolabs Scientific Support)

PIM3, modulated by the LINC01232/miR-370-5p axis, promotes cell proliferation, migration, and invasion in bladder cancer. Feb 17 2021

chat Taylor Smith (Verified Customer)

What is the role of PIM3 in gastric cancer? Mar 23 2023

chat Patrick Liam (Creative Biolabs Scientific Support)

The FALEC/miR-203b/PIM3 axis induces malignant behaviors in gastric cancer cells, suggesting a potential therapeutic target. Mar 23 2023

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