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    mProX™ Human PIM2 Stable Cell Line

    [CAT#: S01YF-1023-PY56]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    Kinase Cell Lines

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    Host Cell Type:
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    Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

    Sub Cat Product Name Target Protein Species Host Cell Type Assay Types Inquiry Datasheet
    S01YF-1222-KX435 Magic™ Human PIM2 in Vitro Assay Human Kinase Assay

    Product Information

    Target Family
    Kinases/Enzyme
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1;HepG2;Huh-7
    Target Classification
    Kinase Cell Lines
    Target Research Area
    Cancer Research
    Related Diseases
    Colorectal Adenocarcinoma; Lymphoma
    Gene ID
    Human:11040
    UniProt ID
    Human:Q9P1W9

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    PIM2, a family of serine/threonine kinases, has been found to play important roles in various diseases and conditions. In the context of cardiovascular disease, PIM kinases have been associated with cell survival, proliferation, and migration. They have widespread expression in cardiovascular tissues and have been implicated in inflammation, thrombosis, and cardiac injury. Inhibition of PIM kinases may be a potential therapeutic approach for treating cardiovascular disease. In the field of pediatric medicine, PIM2 has been used as a predictive tool for assessing the mortality risk in children with severe sepsis and septic shock. It has also been studied in the context of neurocognitive and psychological disorders in children after intensive care admission. Additionally, PIM2 has been investigated in the management of critically ill children with respiratory failure and in the safety and efficacy of continuous renal replacement therapy in children weighing less than 10 kg. Overall, PIM2 has shown promise as a potential target for therapeutic interventions in various disease settings.

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    Please visit our protocols page.

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    FAQ

    chat Cameron Williams (Verified Customer)

    How does PIM2 affect glycolysis and cell proliferation in endometriosis? Apr 18 2023

    chat Patrick Liam (Creative Biolabs Scientific Support)

    PIM2 mediates phosphorylation of PFKFB4, regulating glycolysis and promoting cell proliferation in endometriosis, suggesting its potential as a target for non-contraceptive treatments. Apr 18 2023

    chat Jordan Johnson (Verified Customer)

    What is the role of PIM2 in multiple myeloma? Dec 31 2020

    chat Patrick Liam (Creative Biolabs Scientific Support)

    PIM2 kinase plays a pivotal role in plasmablast generation and plasma cell survival in multiple myeloma, making it a potential therapeutic target. Dec 31 2020

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    • mProX™ Human PIM2 Stable Cell Line (CAT#: S01YF-1023-PY56)
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