mProX™ Human PAK5 Stable Cell Line

[CAT#: S01YF-1023-PY44]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1222-KX419	Magic™ Human PAK5(PAK7) in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;HeLa;SiHa

Target Classification

Kinase Cell Lines

Target Research Area

Cancer Research

Related Diseases

Breast Large Cell Neuroendocrine Carcinoma; Trichorhinophalangeal Syndrome, Type I

Gene ID

Human:57144

UniProt ID

Human:Q9P286

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

PAK5 was found within genomic regions associated with resistance, suggesting its potential role in immune system and inflammatory response functions. In cancer research, PAK5 was shown to be involved in inhibiting the progression of cervical cancer. HPV E7 was found to promote cervical cancer progression by modulating the m6A modification of PAK5, suggesting PAK5 as a potential therapeutic target for cervical cancer. PAK5 was also found to be involved in the regulation of microRNA biogenesis through Drosha phosphorylation. This mechanism of regulation may have implications in cancer and other diseases. In the context of spinal cord injury, inhibiting the mitochondrial docking protein Snph, which is involved in mitochondrial transport, can enhance axonal mitochondrial transport and improve the regeneration of axons. PAK5 may play a role in this process by enhancing mitochondrial transport.

Protocols

Please visit our protocols page.

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FAQ

chat Taylor Williams (Verified Customer)

How does PAK5 influence neuron survival and regeneration? Sep 22 2023

chat Patrick Liam (Creative Biolabs Scientific Support)

PAK5 is involved in an energetic AKT-PAK5 axis that facilitates neuron survival and regeneration after injury and ischemia by maintaining axon energy supply. Sep 22 2023

chat Skyler Miller (Verified Customer)

What role does PAK5 play in breast cancer? Jan 26 2021

chat Patrick Liam (Creative Biolabs Scientific Support)

PAK5-mediated AIF phosphorylation inhibits its nuclear translocation, promoting breast cancer tumorigenesis. Jan 26 2021

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