mProX™ Human P2RX2 Stable Cell Line

Product Information

Target Family

Other Targets

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1

Target Classification

Other Targets Drug Discovery Assays and Products

Target Research Area

CNS Research

Related Diseases

Deafness, Autosomal Dominant 41; Rare Autosomal Dominant Non-Syndromic Sensorineural Deafness Type Dfna

Gene ID

Human:22953

UniProt ID

Human:Q9UBL9

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The P2RX2 gene has various applications in different fields. In the context of genetic hearing loss, P2RX2 is involved in the diagnosis, management, and genetic counseling of this condition. In prostate cancer, P2RX2 is identified as a biomarker for prognosis and immune infiltration levels, and its downregulation is associated with poor survival. In cases of overactive bladder, P2RX2 is one of the genes implicated in the condition, and its expression is upregulated. Additionally, in a study on learning and memory impairment, disruption of P2RX2 signaling in the hippocampus was found to contribute to cognitive dysfunction. Overall, P2RX2 has implications in genetic hearing loss, prostate cancer, overactive bladder, and cognitive function.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Skyler Smith (Verified Customer)

How does P2RX2 expression relate to prostate cancer prognosis? Nov 28 2020

chat Patrick Liam (Creative Biolabs Scientific Support)

P2RX2 has been identified as a biomarker for early diagnosis, prognosis prediction, and aiding treatment decisions in prostate cancer, with its expression associated with clinical outcomes and immune infiltration. Nov 28 2020

chat Jordan Miller (Verified Customer)

What is the role of P2RX2 in hearing loss? Jul 30 2020

chat Patrick Liam (Creative Biolabs Scientific Support)

Mutations in the P2RX2 gene are associated with autosomal dominant deafness, with its role being essential for acoustic information transfer and hearing function. Jul 30 2020

Published Data

Fig.1 ATP hydrolysis was measured in live HEK293 cells expressing WT, V60L, and G353R P2RX2.

In live cells, the determination of ATP hydrolysis was carried out after transfection with both WT and mutant forms of P2RX2 in HEK293 cells. It was noted that significantly reduced inorganic phosphate (iP) release was observed in HEK293 cells expressing V60L P2RX2 when compared to WT or G353R P2RX2 (P < 0.001).

Ref: Mittal, Rahul, et al. "Characterization of ATPase activity of P2RX2 cation channel." Frontiers in physiology 7 (2016): 186.

Pubmed: 27252659

DOI: 10.3389/fphys.2016.00186

Research Highlights

Li, Qinyu. et al. "Identification of Calcium Channel-Related Gene P2RX2 for Prognosis and Immune Infiltration in Prostate Cancer." Disease markers, 2022.
The research discussed focuses on the role of calcium signaling in the progression of prostate cancer, specifically in relation to immune cell function. Through an integrated analysis of various data sources, including The Cancer Genome Atlas database, the researchers identified the calcium channel-related gene P2RX2 as a potential key player in immune cell infiltration levels and prognosis for prostate cancer patients. Further investigations, including in-vitro experiments, provided evidence supporting the potential use of P2RX2 as a biomarker for early diagnosis, prognosis prediction, and treatment decisions in prostate cancer. Additionally, drug sensitivity analysis revealed that patients with low P2RX2 expression may benefit from specific treatments.
Li, Qinyu. et al. "Identification of Calcium Channel-Related Gene P2RX2 for Prognosis and Immune Infiltration in Prostate Cancer." Disease markers, 2022.
Pubmed: 36246559 DOI: 10.1155/2022/8058160