mProX™ Human OXSR1 Stable Cell Line

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1222-KX409	Magic™ Human OSR1(OXSR1) in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;THP-1

Target Classification

Kinase Cell Lines

Target Research Area

Ocular Research

Related Diseases

Hypomagnesemia 4, Renal; Arthrogryposis, Distal, Type 3

Gene ID

Human:9943

UniProt ID

Human:O95747

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

OXSR1, also known as oxidative stress-responsive 1, is a protein that has been studied in various contexts related to different diseases. In septic myocardial injury, it was found that circROCK1 promotes myocardial injury in septic mice by regulating the miR-96-5p/OXSR1 axis. In sepsis-induced acute kidney injury (AKI), circ_0002131 was shown to promote LPS-induced HK-2 cell injury through the miR-942-5p/OXSR1 axis. Moreover, in postparturient endometritis in Holstein cattle, low expression of OXSR1 was associated with the disease. However, in a study on kidney damage induced by low potassium intake, high sodium intake did not worsen the kidney injury or affect OXSR1 expression. Finally, in the context of autosomal dominant polycystic kidney disease (ADPKD), compound-10 and farnesiferol B were identified as potential hits for targeting OXSR1, among other ADPKD targets, suggesting their potential use in the treatment of ADPKD. These findings suggest the diverse applications and importance of OXSR1 in different diseases and provide potential targets for therapeutic intervention.

Protocols

Please visit our protocols page.

Customer Reviews

There are currently no Customer reviews or questions for mProX™ Human OXSR1 Stable Cell Line (S01YF-1023-PY34). Click the button above to contact us or submit your feedback about this product.

FAQ

chat Alex Smith (Verified Customer)

How does OXSR1 participate in the immune response to mycobacterial infections? Dec 11 2021

chat Patrick Liam (Creative Biolabs Scientific Support)

OXSR1 is upregulated in response to mycobacterial infections, aiding the growth of pathogenic mycobacteria and playing a role in immunity. Dec 11 2021

chat Taylor Williams (Verified Customer)

Is there a link between OXSR1 and asthma exacerbation? Jul 05 2020

chat Patrick Liam (Creative Biolabs Scientific Support)

Genetic variants of OXSR1, which are involved in salt transport, immune response, and oxidative stress, may be associated with the risk of asthma exacerbation. Jul 05 2020

Published Data

Fig.1 The growth of M. tuberculosis in human THP-1 cells is facilitated by OXSR1.

The intracellular burden of M. marinum was quantified in differentiated THP-1 cells with WT and OXSR1 knockdown at 1 dpi (left panel), and the intracellular burden of M. tuberculosis was quantified in differentiated THP-1 cells with WT and OXSR1 knockdown at 3 dpi (right panel).

Ref: Hortle, Elinor, et al. "OXSR1 inhibits inflammasome activation by limiting potassium efflux during mycobacterial infection." Life Science Alliance 5.9 (2022).

Pubmed: 35545295

DOI: 10.26508/lsa.202201476

Research Highlights

He, ZhiYu. et al. "circROCK1 Promotes septic myocardial injury through regulating miR-96-5p/OXSR1 axis." Acta biochimica Polonica, 2023.
A recent high-throughput sequencing analysis found that circular RNA Rho-associated kinase 1 (circROCK1) is significantly overexpressed in cases of sepsis. The involvement of circROCK1 in the development of sepsis, however, has not been thoroughly examined. The aim of this study was to examine the role of circROCK1 in myocardial injury induced by sepsis and identify its potential downstream molecular mechanism.
He, ZhiYu. et al. "circROCK1 Promotes septic myocardial injury through regulating miR-96-5p/OXSR1 axis." Acta biochimica Polonica, 2023.
Pubmed: 37721476 DOI: 10.18388/abp.2020_6547

Zhang, Pengjie. et al. "CIRC_0002131 CONTRIBUTES TO LPS-INDUCED APOPTOSIS, INFLAMMATION, AND OXIDATIVE INJURY IN HK-2 CELLS VIA INHIBITING THE BINDING BETWEEN MIR-942-5P AND OXSR1." Shock (Augusta, Ga.), 2023.
In the context of sepsis-associated acute kidney injury (AKI), it has been suggested that circular RNAs play a significant role in its progression. Specifically, Circ_0002131 has been determined to aggravate cell inflammation and oxidative stress in sepsis-induced AKI. The purpose of this investigation was to explore the involvement and underlying mechanism of circ_0002131 in sepsis-induced AKI. Through the use of various assays, it was found that Circ_0002131 was highly expressed in both LPS-treated HK-2 cells and sepsis-induced AKI patients, and its depletion attenuated LPS-induced apoptosis, inflammation, and oxidative injury in HK-2 cells. Further analysis revealed that Circ_0002131 acts through the regulation of miR-942-5p, which in turn affects the expression of OXSR1 and plays a role in preventing LPS-induced cell injury. These findings suggest the potential involvement of the circ_0002131/miR-942-5p/OXSR1 axis in the progression of sepsis-induced AKI.
Zhang, Pengjie. et al. "CIRC_0002131 CONTRIBUTES TO LPS-INDUCED APOPTOSIS, INFLAMMATION, AND OXIDATIVE INJURY IN HK-2 CELLS VIA INHIBITING THE BINDING BETWEEN MIR-942-5P AND OXSR1." Shock (Augusta, Ga.), 2023.
Pubmed: 37549022 DOI: 10.1097/SHK.0000000000002197