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    mProX™ Human OXSR1 Stable Cell Line

    [CAT#: S01YF-1023-PY34]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    Kinase Cell Lines

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    Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

    Sub Cat Product Name Target Protein Species Host Cell Type Assay Types Inquiry Datasheet
    S01YF-1222-KX409 Magic™ Human OSR1(OXSR1) in Vitro Assay Human Kinase Assay

    Product Information

    Target Family
    Kinases/Enzyme
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1;THP-1
    Target Classification
    Kinase Cell Lines
    Target Research Area
    Ocular Research
    Related Diseases
    Hypomagnesemia 4, Renal; Arthrogryposis, Distal, Type 3
    Gene ID
    Human:9943
    UniProt ID
    Human:O95747

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    OXSR1, also known as oxidative stress-responsive 1, is a protein that has been studied in various contexts related to different diseases. In septic myocardial injury, it was found that circROCK1 promotes myocardial injury in septic mice by regulating the miR-96-5p/OXSR1 axis. In sepsis-induced acute kidney injury (AKI), circ_0002131 was shown to promote LPS-induced HK-2 cell injury through the miR-942-5p/OXSR1 axis. Moreover, in postparturient endometritis in Holstein cattle, low expression of OXSR1 was associated with the disease. However, in a study on kidney damage induced by low potassium intake, high sodium intake did not worsen the kidney injury or affect OXSR1 expression. Finally, in the context of autosomal dominant polycystic kidney disease (ADPKD), compound-10 and farnesiferol B were identified as potential hits for targeting OXSR1, among other ADPKD targets, suggesting their potential use in the treatment of ADPKD. These findings suggest the diverse applications and importance of OXSR1 in different diseases and provide potential targets for therapeutic intervention.

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    FAQ

    chat Alex Smith (Verified Customer)

    How does OXSR1 participate in the immune response to mycobacterial infections? Dec 11 2021

    chat Patrick Liam (Creative Biolabs Scientific Support)

    OXSR1 is upregulated in response to mycobacterial infections, aiding the growth of pathogenic mycobacteria and playing a role in immunity​​. Dec 11 2021

    chat Taylor Williams (Verified Customer)

    Is there a link between OXSR1 and asthma exacerbation? Jul 05 2020

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Genetic variants of OXSR1, which are involved in salt transport, immune response, and oxidative stress, may be associated with the risk of asthma exacerbation​​. Jul 05 2020

    Related Products by Target
    • mProX™ Human OXSR1 Stable Cell Line (CAT#: S01YF-1023-PY34)
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