mProX™ Human NUAK2 Stable Cell Line

[CAT#: S01YF-1023-PY33]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1222-KX408	Magic™ Human NuaK2 in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;C32;SM2-1

Target Classification

Kinase Cell Lines

Target Research Area

CNS Research

Related Diseases

Anencephaly 2; Isolated Anencephaly

Gene ID

Human:81788

UniProt ID

Human:Q9H093

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

NUAK2 (NUAK Family Kinase 2) has various applications in different areas of research. In the field of melanoma, studies have shown that activated Akt expression, which is associated with the recurrence of primary melanomas, can help refine the prognostic and predictive values for relapse in acral melanomas. Additionally, NUAK2 amplification and its coupling with PTEN deficiency contribute to the tumorigenesis of melanomas. In gastric cancer, OTUD7B, a deubiquitinase, stabilizes YAP1 and upregulates NUAK2 expression, promoting cancer progression. In SARS-CoV-2 infection, NUAK2 has been identified as a host-dependency factor for viral entry, suggesting its potential as a target for antiviral therapies. In breast cancer, circ_0000033 sequesters miR-378a-3p to upregulate NUAK2, promoting tumor growth. In prostate stromal cells, silencing NUAK1 and NUAK2, as well as using NUAK inhibitors, can inhibit cell proliferation and contraction. These findings highlight the diverse applications of NUAK2 in various biological processes and disease conditions.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Taylor Brown (Verified Customer)

What role does NUAK2 play in cancer development and tumor progression? Apr 26 2021

chat Patrick Liam (Creative Biolabs Scientific Support)

NUAK2 is important in cancer development and tumor progression, serving as a member of the AMP-activated protein kinase family with links to tumor suppressor pathways. Apr 26 2021

chat Casey Davis (Verified Customer)

How is NUAK2 involved in liver cancer? Jun 09 2023

chat Patrick Liam (Creative Biolabs Scientific Support)

NUAK2 plays a critical role in YAP-driven hepatomegaly and tumorigenesis, indicating its importance in liver cancer development. Jun 09 2023

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