mProX™ Human NUAK1 Stable Cell Line

[CAT#: S01YF-1023-PY32]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1222-KX407	Magic™ Human NuaK1(ARK5) in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;DU-145;PC-3

Target Classification

Kinase Cell Lines

Target Research Area

Cancer Research

Related Diseases

Omphalocele; Endometrial Squamous Cell Carcinoma

Gene ID

Human:9891

UniProt ID

Human:O60285

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The applications of NUAK1 include its role in promoting migration, invasion, and metastasis in liver cancer by regulating the epithelial-to-mesenchymal transition (EMT) process. It is also involved in the pathogenesis of spontaneous cerebral hemorrhage and is considered a potential biomarker and therapeutic target. In nasopharyngeal carcinoma, NUAK1 is upregulated by the lncRNA LINC00958, promoting malignancy. Additionally, NUAK1 is involved in the growth and contraction of human prostate stromal cells, suggesting a potential role in benign prostatic hyperplasia. Overall, NUAK1 has implications in cancer progression, hemorrhagic disorders, and prostate-related conditions.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Alex Smith (Verified Customer)

How does NUAK1 contribute to fibrosis? Aug 02 2021

chat Patrick Liam (Creative Biolabs Scientific Support)

NUAK1 acts as a critical TGF-β-induced activator of YAP in fibroblasts, playing a significant role in the development of fibrosis in human kidneys and mouse tissues. Aug 02 2021

chat Peyton Smith (Verified Customer)

What is the role of NUAK1 in cancer survival and metabolism? Nov 23 2020

chat Patrick Liam (Creative Biolabs Scientific Support)

NUAK1 is critical for maintaining metabolic homeostasis and is linked to the survival of cancer patients, as it regulates the mitochondrial respiratory chain complex and glutamine metabolism. Nov 23 2020

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