mProX™ Human NUAK1 Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Kinase Cell Lines
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Patrick Liam (Creative Biolabs Scientific Support)
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Published Data
Fig.1 In prostate cancer cells, NUAK1 promotes migration and invasion.
Cellular motility was assessed in DU145 and PC-3 cell lines utilizing the transwell assay, with results presented as the mean ± standard deviation from three distinct experiments. Significance was determined at *P<0.05.
Ref: Guan, Yongjun, Hongbo Shi, and Tianlin Xiao. "NUAK1 knockdown suppresses prostate cancer cell epithelial-mesenchymal transition, migration, and invasion through microRNA-30b-5p." International Journal of Clinical and Experimental Pathology 11.12 (2018): 5694.
Pubmed: 31949655
DOI: NA
Research Highlights
Chu, Dong-Xia. et al. "LncRNA HOTAIR Enhances Epithelial-to-mesenchymal Transition to Promote the Migration and Invasion of Liver Cancer by Regulating NUAK1 via Epigenetic Inhibition miR-145-5p Expression." Journal of Cancer, 2023.
The role of LncRNA HOTAIR in the epigenetic regulation of liver cancer carcinogenesis and progression is vital. Prior research indicates that increased expression of HOTAIR is indicative of a poor prognosis. In this investigation, 282 tissue samples and transcriptome sequencing data were used to determine the expression of HOTAIR in liver cancer tissues compared to adjacent non-cancerous tissues. Results indicated a significant upregulation of HOTAIR expression in liver cancer tissues.
Chu, Dong-Xia. et al. "LncRNA HOTAIR Enhances Epithelial-to-mesenchymal Transition to Promote the Migration and Invasion of Liver Cancer by Regulating NUAK1 via Epigenetic Inhibition miR-145-5p Expression." Journal of Cancer, 2023.
Pubmed:
37576402
DOI:
10.7150/jca.85335
Ma, Bao-Jun. et al. "Identification of key genes in spontaneous cerebral hemorrhage and prevention of disease damage: LASSO and SVM regression." Preventive medicine, 2023.
The importance of prevention over treatment has been emphasized, and there has been a concerted effort to reduce the incidence of intracerebral hemorrhage by intervening on its risk factors. The identification of these risk factors through the study of spontaneous intracerebral hemorrhage aids towards achieving the goal of prevention and treatment. In this study, the use of Least Absolute Shrinkage and Selection Operator (LASSO) and Support Vector Machine (SVM) helped eliminate two significant SICH-related genes (NUAK1 and ERO1L). A Venn analysis revealed that four critical genes (VCM1, CRNDE, COL6A2, and HSPB6) were associated with SICH. Further analysis showed that NUAK1 was downregulated, while ERO1L, VCAM1, and COL6A2 were upregulated in the disease group. These four genes were identified as the essential ones for SICH and have the potential to serve as biomarkers and targets for new pharmacotherapies.
Ma, Bao-Jun. et al. "Identification of key genes in spontaneous cerebral hemorrhage and prevention of disease damage: LASSO and SVM regression." Preventive medicine, 2023.
Pubmed:
37473923
DOI:
10.1016/j.ypmed.2023.107633
