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    mProX™ Human NRP1 Stable Cell Line

    [CAT#: S01YF-1023-PY281]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:

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    Host Cell Type:
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    Product Information

    Target Family
    Other Targets
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1;SK-N-AS
    Target Classification
    Other Targets Drug Discovery Assays and Products
    Target Research Area
    Cancer Research;Immunology Research
    Related Diseases
    Covid-19; Pancreatic Cancer
    Gene ID
    Human:8829
    UniProt ID
    Human:O14786

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    The vascular endothelial growth factor coreceptor neuropilin-1 (NRP-1) has various applications in different fields. In the context of human immunodeficiency virus (HIV), NRP-1 is associated with proteins involved in angiogenesis, signal transduction, immunoregulation, and cell migration/adhesion. It is also linked to host factors, incident cardiovascular disease, and cancer. NRP-1 is associated with an increased hazard of multiple cancers but a decreased risk of prostate cancer. Additionally, NRP-1 is strongly associated with mortality and type 2 myocardial infarction. In knee osteoarthritis, NRP-1 is one of the major surface markers of pathogenic synovial fluid extracellular vesicles. In renal fibrosis, NRP-1 promotes fibrotic responses in renal tubular epithelial cells. Lastly, in cancer therapy, NRP-1 is targeted by tumor-penetrating peptides for improved treatment outcomes. Activation of the aryl hydrocarbon receptor inhibits NRP-1 upregulation on IL-2 responding CD4 (+) T cells.

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    Customer Reviews

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    FAQ

    chat Casey Garcia (Verified Customer)

    What is the significance of NRP1 in cancer cell behavior? Feb 26 2021

    chat Patrick Liam (Creative Biolabs Scientific Support)

    NRP1 upregulation can promote processes like epithelial-mesenchymal transition in nasopharyngeal carcinoma cells, indicating its role in cancer progression. Feb 26 2021

    chat Peyton Brown (Verified Customer)

    Can NRP1 be a target for cancer therapy? Apr 09 2020

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Targeting NRP1 in cancers like medulloblastoma can potentiate radioresistance and impact cancer stem cells, suggesting its therapeutic potential. Apr 09 2020

    Related Products by Target
    • Magic™ Human NRP1 HEK293T Cell Line (CAT#: S01YF-0123-KX291)
    • mProX™ Human NRP1 Stable Cell Line (CAT#: S01YF-1023-PY281)
    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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