mProX™ Human NRP1 Stable Cell Line

R Schnittman, Samuel. et al. "Biological and Clinical Implications of the Vascular Endothelial Growth Factor Coreceptor Neuropilin-1 in Human Immunodeficiency Virus." Open forum infectious diseases, 2023.
The largest association with coronary plaque in the Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE) proteomics analysis was found in the plasma vascular endothelial growth factor (VEGF) coreceptor neuropilin-1 (NRP-1). The relationship between NRP-1 and other proteins in people with human immunodeficiency virus (PWH) was explored within REPRIEVE, and further validated in a Centers for AIDS Research Network of Integrated Clinical Systems (CNICS) case-cohort study. Within REPRIEVE, NRP-1 showed connections to proteins involved in angiogenesis, signal transduction, immunoregulation, and cell migration/adhesion. In the CNICS study, associations were found between NRP-1 and important host factors such as older age and male sex, as well as an increased risk of multiple cancers and a decreased risk of prostate cancer. These findings also suggest a strong connection between NRP-1 and mortality and type 2 myocardial infarction, indicating its role in a potentially significant immunoregulatory pathway related to multiple comorbidities in PWH.
R Schnittman, Samuel. et al. "Biological and Clinical Implications of the Vascular Endothelial Growth Factor Coreceptor Neuropilin-1 in Human Immunodeficiency Virus." Open forum infectious diseases, 2023.
Pubmed: 37869406   DOI: 10.1093/ofid/ofad467

Zhang, Xin. et al. "Comprehensive characterization of pathogenic synovial fluid extracellular vesicles from knee osteoarthritis." Clinical immunology (Orlando, Fla.), 2023.
The study observed Synovial fluid (SF) extracellular vesicles (EVs) and their role in osteoarthritis (OA). The surface markers, cell and tissue origins, and effectors of these EVs are yet to be fully understood. A total of 692 peptides were identified in SF EVs, and they were positively correlated with the severity of knee radiographic OA. The majority of these peptides (57.4%) were associated with the innate immune system. CSPG4, BGN, NRP1, and CD109 were identified as the major surface markers of pathogenic SF EVs. Further analysis showed that chondrocytes in damaged cartilage significantly expressed the genes for CSPG4 and CD109, while synovial immune cells expressed VISG4, MARCO, CD163, and NRP1. The presence of CSPG4+ EVs in SF was found to be associated with the severity of knee OA.
Zhang, Xin. et al. "Comprehensive characterization of pathogenic synovial fluid extracellular vesicles from knee osteoarthritis." Clinical immunology (Orlando, Fla.), 2023.
Pubmed: 37866785   DOI: 10.1016/j.clim.2023.109812