mProX™ Human NR1H4 Stable Cell Line

[CAT#: S01YF-1123-KX102]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Nuclear Receptor

Certificate of Analysis Lookup
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Lot Number

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Product Information

Target Protein

NR1H4

Target Family

Liver X Receptor

Target Protein Species

Human

Host Cell Type

HT29; CHO-K1; HEK293

Target Classification

Nuclear Receptor

Target Research Area

Digestive and Renal Research; Metabolic Research

Related Diseases

Cholestasis

Gene ID

9971

UniProt ID

Q96RI1

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The human NR1H4 gene encodes the bile acid receptor (BAR), often referred to as the farnesoid X receptor (FXR) or NR1H4. It is a nuclear receptor. The intestine and liver both exhibit significant levels of FXR expression. Natural FXR ligands include bile acids such as chenodeoxycholic acid. Like other nuclear receptors, FXR translocates to the cell nucleus upon activation, forms a dimer, and binds to DNA regions known as hormone response elements to either up- or down-regulate the production of specific genes. Suppression of cholesterol 7 alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in the manufacture of bile acid from cholesterol, is one of the main effects of FXR activation. The customized NR1H4 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat Patricia

I can confidently say that the NR1H4 cell line is a fantastic tool. It has significantly improved the accuracy and precision of our experiments. Apr 25 2023

chat Verified Customer

chat James

This mouse NR1H4 KO cell line is the best choice for laboratories wishing to minimise troubleshooting time. Sep 22 2022

chat Verified Customer

FAQ

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