mProX™ Human NEK7 Stable Cell Line

[CAT#: S01YF-1023-PY28]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1222-KX403	Magic™ Human NEK7 in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;SMMC-7721;HepG2

Target Classification

Kinase Cell Lines

Target Research Area

Metabolic Research

Related Diseases

Muckle-Wells Syndrome; Cinca Syndrome

Gene ID

Human:140609

UniProt ID

Human:Q8TDX7

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

NEK7, a member of the NEK kinase family, has been found to be differentially expressed in various diseases. In esophageal adenocarcinoma (EAC) and its precancerous condition Barrett's esophagus (BE), NEK2, NEK3, and NEK6 were upregulated in EAC, while NEK1 was downregulated. NEK7 has also been implicated in liver sterile inflammatory injury, where its inhibition protected against inflammation, oxidative stress, and iron overload. In osteoarthritis (OA), NEK7 was found to be modified by m6A methylation and its regulation by METTL3 inhibited OA progression. In Alzheimer's disease, NEK7 was associated with cognitive impairment, inflammation, and oxidative stress. Additionally, NEK7 was found to play a role in NLRP3 inflammasome activation during Pasteurella multocida infection. These findings suggest that NEK7 may have important implications in various diseases and could be a potential therapeutic target.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Alex Garcia (Verified Customer)

How does NEK7 contribute to cancer progression? Mar 05 2020

chat Patrick Liam (Creative Biolabs Scientific Support)

Overexpression of NEK7 leads to the progression of different cancers, playing a key role in spindle assembly and mitotic division of the cell. Mar 05 2020

chat Skyler Davis (Verified Customer)

What is the current understanding of NEK7's role in cell cycle regulation? Jul 12 2022

chat Patrick Liam (Creative Biolabs Scientific Support)

NEK7 has a physiological role in regulating the cell cycle and promoting the mitotic process of cells. Jul 12 2022

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