mProX™ Human NEK6 Stable Cell Line

[CAT#: S01YF-1023-PY27]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1222-KX402	Magic™ Human NEK6 in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;HeLa

Target Classification

Kinase Cell Lines

Gene ID

Human:10783

UniProt ID

Human:Q9HC98

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

NEK6, a member of the NEK (Never in mitosis A (NIMA) related kinase) gene family, has been found to be differentially expressed in various diseases and has implications in tumorigenesis, tumor progression, drug resistance, neurodevelopmental disorders, and macrophage polarization. In esophageal adenocarcinoma (EAC) and its precancerous condition, NEK6 was found to be significantly upregulated. NEK6 also plays a role in promoting axon targeting in neural development. In macrophages, NEK6 knockdown polarized them into a pro-inflammatory phenotype. Additionally, NEK6 was found to promote the progression of osteosarcoma by activating the STAT3 signaling pathway and was identified as a potential therapeutic target for hepatocellular carcinoma (HCC). These studies highlight the diverse applications of NEK6 in various diseases and biological processes.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Alex Miller (Verified Customer)

How does NEK6 contribute to tumorigenesis? Sep 18 2022

chat Patrick Liam (Creative Biolabs Scientific Support)

NEK6 is involved in cell cycle control and plays significant roles in tumorigenesis. Sep 18 2022

chat Taylor Miller (Verified Customer)

What is the relationship between NEK6 and castration-resistant prostate cancer (CRPC)? May 29 2023

chat Patrick Liam (Creative Biolabs Scientific Support)

NEK6 is a central kinase in developing CRPC, influencing cancer cell adaptation to high reactive oxygen species (ROS) levels and avoiding cell death by increasing antioxidant defenses. May 29 2023

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