mProX™ Human NEK4 Stable Cell Line

[CAT#: S01YF-1023-PY26]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1222-KX401	Magic™ Human NEK4 in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;A549

Target Classification

Kinase Cell Lines

Target Research Area

Orphan Receptor Research

Related Diseases

Ciliopathy

Gene ID

Human:6787

UniProt ID

Human:P51957

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

NEK4 (NIMA-related kinase 4) has been identified as a potential therapeutic target for various psychiatric disorders. In a study focused on Mendelian randomization analysis, NEK4 was found to be a promising drug target for schizophrenia and bipolar disorder, supported by strong genetic evidence. Additionally, in a transcriptome-wide association study on migraines, NEK4 was identified as a candidate susceptibility gene. Another study investigating neuropsychiatric and substance use disorders found that NEK4, along with other genes, may contribute to the risk of these disorders. Furthermore, a study exploring the genetic associations between bipolar disorder and brain structural phenotypes revealed a shared genetic basis between BD and NEK4. These findings indicate that NEK4 may play a role in psychiatric disorders and could serve as a potential target for therapeutic interventions.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Cameron Williams (Verified Customer)

How does NEK4 regulate epithelial-to-mesenchymal transition (EMT) and cancer metastasis? Jul 23 2022

chat Patrick Liam (Creative Biolabs Scientific Support)

NEK4 acts as a positive regulator of EMT, promoting cell migration and invasion. Its suppression results in increased expression of cell adhesion-related proteins such as E-cadherin and ZO1. Jul 23 2022

chat Peyton Miller (Verified Customer)

What is the role of NEK4 in replicative senescence and DNA damage response? Aug 15 2021

chat Patrick Liam (Creative Biolabs Scientific Support)

NEK4-suppressed cells show impaired cell cycle arrest in response to double-stranded DNA damage. NEK4 is involved in a complex containing DNA-dependent protein kinase catalytic subunit (DNA-PKcs), Ku70, and Ku80, playing a role in the DNA damage response. Aug 15 2021

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