mProX™ Human NEK2 Stable Cell Line

[CAT#: S01YF-1023-PY24]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1222-KX399	Magic™ Human NEK2 in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;OCI-Ly3;SU-DHL-4

Target Classification

Kinase Cell Lines

Target Research Area

Ocular Research;CNS Research

Related Diseases

Retinitis Pigmentosa 67; Retinitis Pigmentosa

Gene ID

Human:4751

UniProt ID

Human:P51955

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

NEK2, a serine/threonine kinase, is involved in various aspects of cancer development and treatment. In multiple myeloma, inhibiting NEK2 can reshape the tumor microenvironment by reducing tumor-associated macrophages and decreasing T cell exhaustion, leading to an enhanced anti-cancer immune response. In esophageal adenocarcinoma, NEK2 and other members of the NEK kinase family are upregulated, suggesting their role in tumorigenesis and progression. In lymphoma, NEK2 inhibition with NBI-961 has shown promising results by compromising cell fitness, inducing cell cycle arrest and apoptosis, and suppressing tumor growth. Additionally, NEK2 has been identified as a potential therapeutic target for cancer treatment, including in diffuse large B-cell lymphoma, where high NEK2 expression is associated with inferior overall survival. The inhibition of NEK2 may overcome tumor immune escape and support the development of anti-NEK2 therapeutic strategies. Overall, NEK2 plays a significant role in cancer biology and has potential applications as a target for cancer therapy.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Jordan Miller (Verified Customer)

What is the primary function of NEK2 in cells? May 12 2020

chat Patrick Liam (Creative Biolabs Scientific Support)

NEK2 is a serine/threonine-protein kinase that localizes to centrosomes and kinetochores, controlling centrosome separation and playing a critical role in cell cycle regulation. May 12 2020

chat Taylor Miller (Verified Customer)

What cellular abnormalities are linked to aberrant NEK2 regulation? Jun 06 2023

chat Patrick Liam (Creative Biolabs Scientific Support)

Aberrant regulation of NEK2 activity can lead to aneuploid defects characteristic of cancer cells. Jun 06 2023

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