mProX™ Human NEK2 Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Kinase Cell Lines
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Made to Order Inquiry
InquiryProduct Information
Product Properties
Protocols
Please visit our protocols page.
Customer Reviews
There are currently no Customer reviews or questions for mProX™ Human NEK2 Stable Cell Line (S01YF-1023-PY24). Click the button above to contact us or submit your feedback about this product.
Jordan Miller (Verified Customer)
Patrick Liam (Creative Biolabs Scientific Support)
Taylor Miller (Verified Customer)
Patrick Liam (Creative Biolabs Scientific Support)
Published Data
Fig.1 In OCI-Ly3 and SU-DHL-4, EdU-positive cells from NEK2 knockdown groups were found in regions with lower cell density than the control group.
NEK2 actively fosters cell growth while suppressing programmed cell death. Displayed are illustrative visuals of EdU staining alongside corresponding statistical data concerning the rate of EdU-positive cells, serving as a demonstrative indicator of NEK2's augmentation of cellular proliferation (statistical significance denoted as *P < 0.05, **P < 0.01, ***P < 0.001, as determined by Student's t-test).
Ref: Zhou, Lingna, et al. "NEK2 promotes cell proliferation and glycolysis by regulating PKM2 abundance via phosphorylation in diffuse large B-cell lymphoma." Frontiers in Oncology 11 (2021): 677763.
Pubmed: 34168996
DOI: 10.3389/fonc.2021.677763
Research Highlights
Lischer, Christopher; Bru, Heiko. "Breaking barriers: NEK2 inhibition shines in multiple myeloma treatment." Cell reports. Medicine, 2023.
In this article, Cheng et al. discuss the influence of social media on the mental well-being of adolescents. Through their examination, they highlight the potential negative effects that excessive social media use may have on teenage mental health. They also suggest possible interventions and strategies for parents, educators, and mental health professionals to mitigate these negative impacts and promote positive social media usage among teenagers. Their findings highlight the importance of addressing this issue and promoting healthy social media habits for teenagers.
Lischer, Christopher; Bru, Heiko. "Breaking barriers: NEK2 inhibition shines in multiple myeloma treatment." Cell reports. Medicine, 2023.
Pubmed:
37852178
DOI:
10.1016/j.xcrm.2023.101237
Chen, Lei. et al. "Differential Expression of NEK Kinase Family Members in Esophageal Adenocarcinoma and Barrett's Esophagus." Cancers, 2023.
The incidence of esophageal adenocarcinoma (EAC) has rapidly increased in the past four decades, making it the most common type of esophageal cancer in the USA and Western countries. The NEK (Never in mitosis A (NIMA) related kinase) gene family, which consists of 11 serine/threonine kinases, has been implicated in the development and progression of various human cancers. However, the expression of NEKs in EAC and its precursor condition, Barrett's esophagus (BE), has not been thoroughly investigated. Through bioinformatic analysis of 10 databases, including TCGA and 9 GEO databases, we found significant upregulation of NEK2, NEK3, and NEK6 in EAC compared to normal esophagus samples. We also observed downregulation of NEK1 in EAC. These findings were substantiated by qRT-PCR, Western blotting, and immunohistochemistry analysis of NEK expression in EAC cell lines and primary EAC tissues. Our results suggest a potential role for NEK2, NEK3, and NEK6 in the development of EAC.
Chen, Lei. et al. "Differential Expression of NEK Kinase Family Members in Esophageal Adenocarcinoma and Barrett's Esophagus." Cancers, 2023.
Pubmed:
37835513
DOI:
10.3390/cancers15194821
