mProX™ Human NEK1 Stable Cell Line

Goberg Olsen, Cathrine. et al. "Genetic overlap between ALS and other neurodegenerative or neuromuscular disorders." Amyotrophic lateral sclerosis & frontotemporal degeneration, 2023.
This paper outlines the effects of various forms of social media on individuals' abilities to communicate. It evaluates the advantages and disadvantages of utilizing platforms such as Facebook, Instagram, and Twitter for communication purposes. The authors analyze the impact of these mediums on both verbal and nonverbal communication, as well as their influence on relationships and personal interactions. The findings suggest the importance of maintaining a healthy balance between online and in-person communication, and provide strategies for effectively utilizing social media.
Goberg Olsen, Cathrine. et al. "Genetic overlap between ALS and other neurodegenerative or neuromuscular disorders." Amyotrophic lateral sclerosis & frontotemporal degeneration, 2023.
Pubmed: 37849306   DOI: 10.1080/21678421.2023.2270705

Chen, Lei. et al. "Differential Expression of NEK Kinase Family Members in Esophageal Adenocarcinoma and Barrett's Esophagus." Cancers, 2023.
The incidence of esophageal adenocarcinoma (EAC) has been steadily increasing over the past forty years, making it the most prevalent form of esophageal cancer in the United States and other Western countries. Recent studies have shown that the NEK (Never in Mitosis A (NIMA) Related Kinase) gene family, which consists of eleven serine/threonine kinases, plays a significant role in various types of human cancers, including EAC. However, there has been limited research on the expression of NEKs in EAC and its precursor condition, Barrett's esophagus (BE). In this study, researchers utilized bioinformatic approaches to analyze data from ten databases, including the TCGA and 9 GEO databases, to investigate the expression of NEKs in EAC and BE. Their analysis revealed a significant upregulation of NEK2, NEK3, and NEK6 in EAC compared to normal esophagus samples, while NEK1 was downregulated. However, genomic alterations of these NEKs were not found to be frequent in EAC. These findings were further validated through experiments using qRT-PCR, Western blotting, and immunohistochemistry on EAC cell lines and primary EAC tissues. The results indicate that NEK2, NEK3, and NEK7 may play a crucial role in EAC development and progression.
Chen, Lei. et al. "Differential Expression of NEK Kinase Family Members in Esophageal Adenocarcinoma and Barrett's Esophagus." Cancers, 2023.
Pubmed: 37835513   DOI: 10.3390/cancers15194821