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    mProX™ Human NEK1 Stable Cell Line

    [CAT#: S01YF-1023-PY23]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    Kinase Cell Lines

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    Host Cell Type:
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    Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

    Sub Cat Product Name Target Protein Species Host Cell Type Assay Types Inquiry Datasheet
    S01YF-1222-KX398 Magic™ Human NEK1 in Vitro Assay Human Kinase Assay

    Product Information

    Target Family
    Kinases/Enzyme
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1;U87
    Target Classification
    Kinase Cell Lines
    Target Research Area
    CNS Research
    Related Diseases
    Amyotrophic Lateral Sclerosis 24; Short-Rib Thoracic Dysplasia 6 With Or Without Polydactyly
    Gene ID
    Human:4750
    UniProt ID
    Human:Q96PY6

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    NEK1, a serine/threonine kinase, has been studied in relation to its applications in amyotrophic lateral sclerosis (ALS) and esophageal adenocarcinoma. In ALS, NEK1 has been found to be associated with genetic causes of the disease, with risk variants present in 2.5% of the ALS cohort. The study also identified other genes that could potentially be ALS-causing genes. In esophageal adenocarcinoma, NEK1 expression was found to be downregulated compared to normal esophagus samples, suggesting that NEK1 may play a role in the development and progression of EAC. Additionally, NEK1 has been found to be involved in microtubule homeostasis and nuclear import, and disruptions in these processes are implicated in ALS pathophysiology. Therefore, NEK1 has been suggested as a potential therapeutic target for ALS. Furthermore, studies on genetic and proteomic risk factors of ALS have explored the potential of NEK1 as a biomarker and its application in gene therapy for ALS treatment.

    Protocols

    Please visit our protocols page.

    Customer Reviews

    There are currently no Customer reviews or questions for mProX™ Human NEK1 Stable Cell Line (S01YF-1023-PY23). Click the button above to contact us or submit your feedback about this product.

    FAQ

    chat Cameron Brown (Verified Customer)

    How does NEK1 affect blood-brain barrier integrity? Mar 26 2023

    chat Patrick Liam (Creative Biolabs Scientific Support)

    NEK1 deficiency disrupts retromer-mediated endosomal trafficking, leading to metabolic and proteomic defects that compromise the integrity of the blood-brain barrier, sensitizing cells to RIPK1-dependent apoptosis and necroptosis. Mar 26 2023

    chat Alex Davis (Verified Customer)

    What is the role of NEK1 in mitochondrial and lysosomal function? Jun 29 2023

    chat Patrick Liam (Creative Biolabs Scientific Support)

    NEK1 regulates retromer-mediated trafficking, which is essential for maintaining mitochondrial and lysosomal function. Its deficiency can lead to mitochondrial and lysosomal dysfunction. Jun 29 2023

    Related Products by Target
    • mProX™ Human NEK1 Stable Cell Line (CAT#: S01YF-1023-PY23)
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