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    mProX™ Human NCR1 Stable Cell Line

    [CAT#: S01YF-1023-PY280]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:

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    Host Cell Type:
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    Product Information

    Target Family
    Other Targets
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1;YT
    Target Classification
    Other Targets Drug Discovery Assays and Products
    Target Research Area
    Cancer Research
    Related Diseases
    Hydatidiform Mole, Recurrent, 1; Gestational Trophoblastic Neoplasm
    Gene ID
    Human:9437
    UniProt ID
    Human:O76036

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    NCR1, also known as NKp46, is a biomarker that plays a role in various immune processes. In a study on vitiligo, the JAK3/TEC family kinase inhibitor ritlecitinib downregulated immune biomarkers and upregulated melanocyte-related markers in the skin and blood of participants, suggesting its potential in treatment. Another study found that STAT4, which is regulated by NCR1, has divergent roles in shaping the differentiation of cytotoxic ILC1 and NK cells during gut inflammation. Methionine enkephalin inhibited cervical cancer migration and activated CD11b(+) NCR1(+) NK cells in the tumor microenvironment. IL-25 was found to regulate metabolism and other biological processes in NK cells, providing insight into its role and regulatory mechanisms. In soft tissue sarcoma, intratumoral NKp46(+) NK cells were associated with improved overall survival and were spatially distanced from T cells and MHC-I(+) cells. These findings have implications for prognosis and immunotherapy treatment selection.

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    Customer Reviews

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    FAQ

    chat Jordan Johnson (Verified Customer)

    What is the role of NCR1 in sterol translocation? May 31 2020

    chat Patrick Liam (Creative Biolabs Scientific Support)

    NCR1 drives sterol translocation across vacuoles in yeast by undergoing conformational changes, suggesting its importance in sterol homeostasis. May 31 2020

    chat Jordan Brown (Verified Customer)

    How does NCR1 contribute to immune responses? Jan 03 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    NCR1, expressed on natural killer cells, plays a role in controlling systemic infections like vaccinia virus through IFN-γ gene function, indicating its importance in immune surveillance. Jan 03 2022

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    • mProX™ Human NCR1 Stable Cell Line (CAT#: S01YF-1023-PY280)
    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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