mProX™ Human MYLK2 Stable Cell Line

[CAT#: S01YF-1023-PY99]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1222-KX488	Magic™ Human skMLCK(MYLK2) in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;BJAB

Target Classification

Kinase Cell Lines

Target Research Area

Cardiovascular Research;Immunology Research

Related Diseases

Cardiomyopathy, Familial Hypertrophic, 1; Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome 1

Gene ID

Human:85366

UniProt ID

Human:Q9H1R3

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

MYLK2, also known as myosin light chain kinase 2, is a protein that has been implicated in various biological processes and diseases. In prostate cancer, MYLK2 is upregulated by the demethylase FTO, which suppresses the progression of the disease. MYLK2 is also found to be strongly correlated with SARS-CoV-2 infection and the prognosis of hepatocellular carcinoma patients. In addition, MYLK2 is associated with insulin sensitivity in muscle biopsies from healthy individuals, and its expression is altered in laying hens with keel bone fractures. Furthermore, MYLK2 is identified as one of the key genes influencing the racing phenotype in galloping racehorse breeds. These findings suggest that MYLK2 may have potential applications in cancer research, infectious diseases, metabolic disorders, and athletic performance.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Alex Smith (Verified Customer)

How are MYLK2 gene mutations related to cardiomyopathy? Apr 22 2023

chat Patrick Liam (Creative Biolabs Scientific Support)

Mutations in the MYLK2 gene are associated with different phenotypes of cardiomyopathy, including hypertrophic cardiomyopathy (HCM). Apr 22 2023

chat Taylor Williams (Verified Customer)

What is the relationship between MYLK2 mutations and long QT syndrome (LQT1) and HCM? Sep 02 2023

chat Patrick Liam (Creative Biolabs Scientific Support)

Tetrad heterozygous mutations in genes including MYLK2 can lead to dual LQT1 and HCM phenotypes. Sep 02 2023

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