mProX™ Human MS4A1 Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

MS4A1, also known as CD20, is a 4-transmembrane protein that functions as a mammalian odorant receptor in a subset of olfactory sensory neurons. It mediates innate avoidance of predators by recognizing compounds produced by mouse predators. CD20 is expressed in a previously uncharacterized subpopulation of olfactory sensory neurons in the murine nasal cavity. Wild-type mice avoid predator odorants, but mice genetically deleted of CD20 do not appropriately respond. This work reveals a novel CD20-mediated odor-sensing mechanism in the mammalian olfactory system that triggers innate behaviors critical for organismal survival. In addition to its role in olfaction, CD20 has also been implicated in lung adenocarcinoma and breast cancer. In lung adenocarcinoma, CD20 is identified as one of the immune-related genes associated with the response to immunotherapy. In breast cancer, CD20 is among the immune-related genes that exhibit associations with the pathologic response to neoadjuvant chemotherapy. Furthermore, CD20 is part of an immune-related gene signature that can predict the prognosis and drug response in lung adenocarcinoma. Overall, CD20 has diverse applications in different fields, including olfaction, cancer immunotherapy, and predicting treatment outcomes in breast and lung cancer.