mProX™ Human MS4A1 Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Immune Checkpoint Cell Lines
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Published Data
Fig.1 The suppression of MS4A1/CD20 mediates the induction of apoptosis in Ramos cells by TGF-β.
Lentiviruses carrying GFP cDNA (Ramos-GFP) and FLAG-tagged MS4A1/CD20 cDNA (Ramos-MS4A1) were used to infect Ramos cells. Subsequently, stimulation with TGF-β3 (1 ng/ml) was administered for 72 h. The counting of percentages of TUNEL-positive cells among total cells in independent fields was carried out, and the data were presented as the mean±s.d.
Ref: Kawabata, K. C., et al. "TGF-β-induced apoptosis of B-cell lymphoma Ramos cells through reduction of MS4A1/CD20." Oncogene 32.16 (2013): 2096-2106.
Pubmed: 22665052
DOI: 10.1038/onc.2012.219
Research Highlights
Jiang, Hao-Ching. et al. "CD20 is a mammalian odorant receptor expressed in a subset of olfactory sensory neurons that mediates innate avoidance of predators." Research square, 2023.
The mammalian olfactory system has the ability to detect and distinguish between numerous odorants in order to produce suitable behavioral responses. Although there is extensive knowledge about how olfactory sensory neurons detect and communicate the presence of these odors, the underlying mechanism of how specific, innate behaviors are initiated in response to ethologically relevant odors is still not fully understood. In this study, it is demonstrated that the 4-transmembrane protein CD20, also known as MS4A1, is expressed in a previously unidentified group of olfactory sensory neurons in the main olfactory epithelium of the mouse nasal cavity. CD20 acts as a mammalian odorant receptor, detecting compounds produced by predators of mice. It was observed that while wild-type mice use this mechanism to avoid predator odorants, mice lacking CD20 do not display the appropriate response. These findings provide new insights into the role of CD20 in odorant sensing in the mammalian olfactory system, and its crucial role in triggering innate behaviors essential for the survival of organisms.
Jiang, Hao-Ching. et al. "CD20 is a mammalian odorant receptor expressed in a subset of olfactory sensory neurons that mediates innate avoidance of predators." Research square, 2023.
Pubmed:
37790559
DOI:
10.21203/rs.3.rs-3290152/v1
Huang, Ling. et al. "Ferroptosis and WDFY4 as novel targets for immunotherapy of lung adenocarcinoma." Aging, 2023.
In the field of oncology, lung cancer has the highest mortality rate compared to other malignant cancers worldwide. This presents a major global challenge in reducing patient mortality. As a novel therapeutic approach, targeted immunotherapy has gained traction for the treatment of lung cancer. This study aims to identify potential targets for immunotherapy in lung adenocarcinoma (LUAD) using Ferroptosis Index (FPI) and Single Cell RNA-Sequencing (scRNA-seq) data analysis. The results of this research have the potential to improve LUAD immunotherapy strategies and inform clinical decision-making.
Huang, Ling. et al. "Ferroptosis and WDFY4 as novel targets for immunotherapy of lung adenocarcinoma." Aging, 2023.
Pubmed:
37728413
DOI:
10.18632/aging.205042
