mProX™ Human MKNK2 Stable Cell Line

Tang, Wenqing. et al. "Identification of SGMS2 as a molecule involved in natural killer cell recruitment and its in-deep analysis in the liver cancer microenvironment: Evidence from large populations cohort." The journal of gene medicine, 2023.
Liver cancer, a frequently encountered malignancy in the digestive system, presents a grim prognosis. The role of natural killer (NK) cells within the immune microenvironment of liver cancer remains uncertain. Using data from The Cancer Genome Atlas Program database and R software, the researchers analyzed clinical parameters and gene expressions in liver cancer patients. Their study focused on genes associated with NK cells in hepatocellular carcinoma (HCC). They utilized QUANTISEQ and MCPCOUNTER algorithms to quantify NK cells and identified genes, including GDE1, WDFY3, DNAJB14, PKD2, DGAT2, SGMS2, and MKNK2, with significant correlations to patient outcomes. SGMS2, in particular, emerged as a key gene with implications in biological pathways, immune landscape, and genomic instability within HCC. The researchers developed a predictive model based on SGMS2-associated genes, showing promising accuracy in training and validation cohorts. In summary, their investigation highlights SGMS2's significance in NK cell infiltration and its potential role in oncological strategies for HCC.
Tang, Wenqing. et al. "Identification of SGMS2 as a molecule involved in natural killer cell recruitment and its in-deep analysis in the liver cancer microenvironment: Evidence from large populations cohort." The journal of gene medicine, 2023.
Pubmed: 37849429   DOI: 10.1002/jgm.3609

Sun, Xiaoli. et al. "Comparative transcriptome analysis of eyes reveals the adaptive mechanism of mantis shrimp (oratosquilla oratoria) induced by a dark environment." Genetica, 2023.
The growth and development of animals are significantly influenced by the light-dark cycle. In the case of mantis shrimps (Oratosquilla oratoria), their complex photoreceptors play a crucial role in detecting light. A comparative transcriptome analysis was conducted to investigate the adaptive expression mechanism of mantis shrimp in a dark environment. The study compared O. oratoria cultured under light (Oo-L) as a control group and those cultured in the dark (Oo-D) as an experimental group. A total of 88 differentially expressed genes (DEGs) were identified, with 78 upregulated and 10 downregulated, between the Oo-L and Oo-D groups. Among the DEGs, FBP1 and Pepck were downregulated, while MKNK2 was upregulated, suggesting a decrease in cell proliferation and metabolic rate in the dark environment. Additionally, gene set enrichment analysis (GSEA) showed a slowing trend in each metabolic pathway in the dark environment. GO enrichment analysis revealed biological processes such as eye development, sensory perception, and sensory organ development. The findings suggest that mantis shrimp slow down their metabolism in the dark environment and rely more on their sensory organs. This study provides valuable insights into the energy metabolism of mantis shrimp and its physiological response to a dark environment.
Sun, Xiaoli. et al. "Comparative transcriptome analysis of eyes reveals the adaptive mechanism of mantis shrimp (oratosquilla oratoria) induced by a dark environment." Genetica, 2023.
Pubmed: 37831421   DOI: 10.1007/s10709-023-00198-6