mProX™ Human MKNK2 Stable Cell Line

[CAT#: S01YF-1023-PY9]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1122-KX1226	Magic™ Human MNK2(MKNK2) in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;SK-OV-3;COC1

Target Classification

Kinase Cell Lines

Gene ID

Human:2872

UniProt ID

Human:Q9HBH9

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

MKNK2 has been identified as a gene that is involved in natural killer (NK) cell recruitment in liver cancer. It has shown a strong correlation with patient outcomes and has been found to contribute to the immune landscape and genomic instability within hepatocellular carcinoma (HCC). In addition, MKNK2 has also been implicated in alternative splicing in prostate cancer, where its expression affects the isoform switch of certain genes involved in tumorigenesis. Furthermore, MKNK2 has been identified as a kinase that regulates the reactivation of Kaposi's sarcoma-associated herpesvirus (KSHV), a virus associated with Kaposi's sarcoma and other diseases. It plays a role in the latent-to-lytic replication switch of KSHV. These studies highlight the potential applications of MKNK2 in the development of oncological strategies, as a potential prognostic biomarker, and as a target for therapeutic intervention.

Protocols

Please visit our protocols page.

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FAQ

chat Morgan Miller (Verified Customer)

What are the functions of different MKNK2 isoforms in cancer? Aug 15 2023

chat Patrick Liam (Creative Biolabs Scientific Support)

MKNK2 can be alternatively spliced into two isoforms, MKNK2a and MKNK2b, each with distinct domains and roles in MAPK signaling and oncogenesis. Aug 15 2023

chat Jordan Brown (Verified Customer)

How does MNK2 (MKNK2) affect β-cell regeneration? Jul 27 2022

chat Patrick Liam (Creative Biolabs Scientific Support)

MKNK2 is the target of a molecule that stimulates pancreatic β-cell generation, indicating its potential role in β-cell regeneration and diabetes treatment. Jul 27 2022

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