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  • mProX™ Human MKNK1 Stable Cell Line

    [CAT#: S01YF-1023-PY8]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    Kinase Cell Lines

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    Host Cell Type:
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    Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

    Sub Cat Product Name Target Protein Species Host Cell Type Assay Types Inquiry Datasheet
    S01YF-1122-KX1225 Magic™ Human MNK1(MKNK1) in Vitro Assay Human Kinase Assay

    Product Information

    Target Family
    Kinases/Enzyme
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1;Huh-7
    Target Classification
    Kinase Cell Lines
    Gene ID
    Human:8569
    UniProt ID
    Human:Q9BUB5

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    MKNK1 (also known as MNK1) is involved in various biological processes and diseases. It has been found to play a role in regulating radiation resistance in colorectal cancer cells, promoting the ability of these cells to proliferate, migrate, invade, and acquire radiation resistance. It is targeted by a tRNA-derived small RNA (tRF-16-7X9PN5D) that is downregulated in radioresistant colorectal cancer cells. Furthermore, MKNK1 is also involved in the modulation of endometrial primary cells during pregnancy in buffaloes, where it is a target gene of miR-195-5p carried by extracellular vesicles. In addition, MKNK1 regulates the latent-to-lytic replication switch of Kaposi's sarcoma-associated herpesvirus, with its knockdown promoting the maintenance of viral latency. Lastly, MKNK1 is among seven genes in the HIF-1 signaling pathway that can be used as a diagnostic signature for preeclampsia. These findings suggest that MKNK1 has applications in cancer, pregnancy, and viral infections, making it a potential target for therapeutic interventions.

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    FAQ

    chat Skyler Johnson (Verified Customer)

    How does MKNK1 influence ovarian endometriosis? Feb 02 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Increased expression levels of MKNK1 have been observed in ectopic and eutopic endometrium compared to normal endometrium in ovarian endometriosis​​. Feb 02 2022

    chat Peyton Davis (Verified Customer)

    What is the relationship between MKNK1 and sepsis? Jul 08 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    MKNK1, targeted by miR-223-3p, may be involved in sepsis by regulating neutrophil abundance and the expression of inflammation factors​​. Jul 08 2022
    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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