mProX™ Human MINK1 Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

MINK1 is a serine/threonine kinase that has been found to have several applications in different fields. In breast cancer, high levels of MINK1 expression have been associated with shorter overall survival of patients, suggesting its possible role in breast cancer development and prognosis. In the context of congenital heart disease (CHD), MINK1 has been identified as a crucial regulator of cell fate determination in the Spemann Organizer, highlighting a potential molecular mechanism connecting CHD and MINK1. MINK1 has also been implicated in Alzheimer's disease risk, as variants in the MINK1 gene have been identified as risk factors for the disease in African American individuals. Additionally, in Th17-dominant asthma, MINK1 is regulated by methyl-CpG binding domain protein 2 (MBD2) and plays a role in the differentiation of Th17 cells, suggesting its potential as a therapeutic target for this type of asthma. Lastly, in the kidney, vasopressin regulates protein phosphorylation, including MINK1, in the collecting duct, indicating its involvement in the control of water excretion. Overall, the research suggests that MINK1 has diverse applications in various diseases and biological processes.