mProX™ Human MELK Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

MELK (maternal embryonic leucine zipper kinase) has various applications in different fields. In pediatric research, MELK is used to develop reference values for parameters of phosphate homeostasis in children. The study provides reference percentiles for key laboratory parameters of phosphate homeostasis that can aid in the interpretation of test results in children and adolescents. In the context of diffuse high-grade gliomas, MELK is studied in comparison to 2D cell cultures and tissue strains to understand its role in tumor progression and characteristics. It is found that 3D spheroids, in which MELK is expressed, more closely mimic tumor tissue compared to 2D cell cultures. In rheumatoid arthritis, MELK is identified as one of the hub genes that could serve as a potential therapeutic target for the disease. In nasopharyngeal carcinoma, MELK is shown to play a role in immune escape, making it a potential target for suppressing the immune evasion of tumor cells. Finally, in colitis-associated colon cancer, MELK is explored for its potential role in reducing initiation and preventing the development of colon cancer associated with inflammatory bowel disease. These studies highlight the diverse applications of MELK in different areas of research and its potential as a target for therapeutic interventions.