mProX™ Human MARK4 Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Kinase Cell Lines
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Published Data
Fig.1 MARK4 attenuates formation of a MST/SAV/LATS complex.
Combinations of Flag-SAV1 and HA-MST2 were used to transfect HEK293T cells, either in the presence or absence of HA-MARK4. After cell lysates were treated to anti-Flag immunoprecipitation, anti-HA and anti-MST1 antibodies were used for immunoblotting, respectively.
Ref: Heidary Arash, Emad, et al. "MARK4 inhibits Hippo signaling to promote proliferation and migration of breast cancer cells." EMBO reports 18.3 (2017): 420-436.
Pubmed: 28183853
DOI: 10.15252/embr.201642455
Research Highlights
The therapeutic investigation of RA and RA-based inhibitors in MARK4-associated malignancies and other disorders is justified by the findings of this study.
Anwar, Saleha, et al. "Rosmarinic acid exhibits anticancer effects via MARK4 inhibition." Scientific Reports 10.1 (2020): 10300.
Pubmed:
32587267
DOI:
10.1038/s41598-020-65648-z
These findings demonstrate how MARK4 precisely controls the detyrosination of microtubules in cardiomyocytes to maintain cardiac inotropy and point to MARK4 as a potential therapeutic target for enhancing cardiac function following myocardial infarction.
Yu, Xian, et al. "MARK4 controls ischaemic heart failure through microtubule detyrosination." Nature 594.7864 (2021): 560-565.
Pubmed:
34040253
DOI:
10.1038/s41586-021-03573-5
