mProX™ Human MARK4 Stable Cell Line

[CAT#: S01YF-1123-KX302]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1122-KX1212	Magic™ Human MARK4 in Vitro Assay	Human		Kinase Assay

Product Information

Target Protein

MARK4

Target Family

Kinases/Enzyme Drug Discovery Assays and Products

Target Protein Species

Human

Host Cell Type

CHO-K1; HEK293

Target Classification

Kinase Cell Lines

Target Research Area

CNS Research; Reproductive Research; Pigmentation Research

Related Diseases

Peutz-Jeghers Syndrome and Parkinson Disease 6, Autosomal Recessive Early-Onset. Among its related pathways are Organelle biogenesis and maintenance and Loss of Nlp from mitotic centrosomes

Gene ID

57787

UniProt ID

Q96L34

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

An enzyme called MAP/microtubule affinity-regulating kinase 4 is encoded by the MARK4 gene in humans. Microtubule-associated proteins (MAP) are phosphorylated by serine/threonine kinases, which causes MAP to separate from microtubules. MARK4 is a member of this family. Detachment thus enhances microtubule dynamics and promotes a variety of cellular processes, such as cell division, control of the cell cycle, determination of cell polarity, and modification of cell shape. It has been demonstrated that MARK4 kinase has a role in the structure of microtubules in neural cells. MARK4 levels are higher in Alzheimer's patients, and this could be related to the disease's abnormal tau protein phosphorylation. The customized MARK4 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat Donna

This MARK4 KO cell line has been a great help to us. Jul 16 2022

chat Verified Customer

chat Charles

The MARK4 cell line is very effective and has good complement activity. Oct 19 2022

chat Verified Customer

FAQ

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