mProX™ Human MARK1 Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Kinase Cell Lines
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Published Data
Fig.1 USP21 regulates the stability of MARK proteins and MARK1 ubiquitylation.
Immunoblots demonstrating how USP21 reduction affects HEK293T cell components involved in the hippocampal pathway. Probes were run on blots using the designated antibodies. Anti-Actin was employed as a loading control.
Ref: Nguyen, Hung Thanh, et al. "USP21 regulates Hippo pathway activity by mediating MARK protein turnover." Oncotarget 8.38 (2017): 64095.
Pubmed: 28969054
DOI: 10.18632/oncotarget.19322
Research Highlights
According to the findings, MARK1 is a novel functional target of miR-125a-5p that has an impact on the migration of tumor cells that are cervical cancer cells.
Natalia, Martínez-Acuna, et al. "MARK1 is a novel target for miR-125a-5p: Implications for cell migration in cervical tumor cells." MicroRNA 7.1 (2018): 54-61.
Pubmed:
29076440
DOI:
10.2174/2211536606666171024160244
Intramolecular autoinhibitory interactions between protein modules are often responsible for the regulation of protein kinases; these interactions are counteracted when the protein modules bind other targets that are membrane-bound or 'activating'.
Emptage, Ryan P., Mark A. Lemmon, and Kathryn M. Ferguson. "Molecular determinants of KA1 domain-mediated autoinhibition and phospholipid activation of MARK1 kinase." Biochemical Journal 474.3 (2017): 385-398.
Pubmed:
27879374
DOI:
10.1042/BCJ20160792
