mProX™ Human MAPK13 Stable Cell Line

[CAT#: S01YF-1023-PY38]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1222-KX413	Magic™ Human p38δ(MAPK13) in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;HEC-1

Target Classification

Kinase Cell Lines

Target Research Area

Cancer Research

Related Diseases

Colorectal Cancer

Gene ID

Human:5603

UniProt ID

Human:O15264

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

MAPK13, also known as p38Œ≥, is a kinase that plays a role in various biological processes, including inflammation and immune response. In respiratory airway diseases, MAPK13 is activated and required for mucus production. Researchers have developed a potent MAPK13-14 inhibitor that effectively down-regulates mucus production and prevents airway inflammation in models of airway disease. In diffuse large B-cell lymphoma, MAPK13 has been found to be expressed more than four-fold in a rituximab-resistant cell line, suggesting an association between MAPK13 activation and rituximab resistance. In cancer cells, m6A modification of MAPK13 mRNA determines the sensitivity to rapamycin, an mTORC1-targeting agent. MAPK13 stabilization limits the anticancer efficacy of rapamycin. Additionally, MAPK13, along with p38Œ¥, has been found to modulate innate immune response by regulating the activation of the transcription factor MEF2D. These studies indicate that MAPK13 has potential applications in the treatment of respiratory diseases, lymphomas, cancer, and modulation of the immune response.

Protocols

Please visit our protocols page.

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FAQ

chat Jordan Jones (Verified Customer)

How does MAPK13 modification affect cancer cell sensitivity to rapamycin? Feb 28 2022

chat Patrick Liam (Creative Biolabs Scientific Support)

m6A modification of MAPK13 mRNA plays a crucial role in determining the sensitivity of cancer cells to the chemotherapeutic agent rapamycin. Feb 28 2022

chat Alex Miller (Verified Customer)

What is the significance of MAPK13 in endometrial carcinoma? Jan 07 2022

chat Patrick Liam (Creative Biolabs Scientific Support)

The circTNFRSF21-miR-1227-MAPK13/ATF2 axis has been identified as a promising target for endometrial carcinoma treatment. Jan 07 2022

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