mProX™ Human MAPK12 Stable Cell Line

[CAT#: S01YF-1023-PY37]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1222-KX412	Magic™ Human p38γ(MAPK12) in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;U2OS

Target Classification

Kinase Cell Lines

Target Research Area

Cancer Research

Related Diseases

Breast Cancer; Colorectal Cancer

Gene ID

Human:6300

UniProt ID

Human:P53778

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

MAPK12, also known as p38Œ≥, has various applications in cancer treatment and immune response regulation. In cancer, targeting p38Œ≥ can be a potential therapeutic strategy for breast cancer, as it plays a significant role in the progression of breast carcinoma. Novel lead molecules, such as 3-deazaadenosine, have been designed using computational drug design methodologies and have shown promise as potential antagonists for breast cancer treatment. In immune response regulation, p38Œ≥ and p38Œ¥ have been found to modulate the innate immune response by regulating the activation of the transcription factor MEF2D. These proteins play a role in regulating inflammation and have been implicated in responses to external stimuli and stress. Additionally, p38Œ≥ and p38Œ¥ are involved in various signaling pathways, including Tlr, Tnf, RIG-I, NOD, NF-Œ∫B, MAPK, and Jak-STAT pathways, which are associated with immune response and pathogen recognition. Overall, MAPK12 has potential applications in cancer therapeutics and immune response modulation.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Taylor Williams (Verified Customer)

Is MAPK12 a potential target for cancer immunotherapy? Sep 09 2022

chat Patrick Liam (Creative Biolabs Scientific Support)

MAPK12 has been identified as a potential prognostic biomarker and immunotherapeutic target in various types of tumors. Sep 09 2022

chat Alex Miller (Verified Customer)

How does MAPK12 influence ovarian cell apoptosis? Sep 14 2022

chat Patrick Liam (Creative Biolabs Scientific Support)

High prolactin concentrations can promote apoptosis in ovarian cells by upregulating MAPK12 expression. Sep 14 2022

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