mProX™ Human MAPK11 Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Kinase Cell Lines
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Published Data
Fig.1 A549, HCT-116, and MCF-7 cell lines exhibit increased radiosensitivity when MAPK11 is genetically abrogated.
Clonogenic assays were conducted on A549, HCT-116, and MCF-7 cells, which were infected with Scramble, shMAPK11, or shMAPK14 and subjected to varying doses of X-rays. The surviving fraction was subsequently normalized with respect to their respective unirradiated controls. The data curves were fitted employing a lineal-quadratic model, and standard deviation (S.D) values were calculated for the bars.
Ref: Fernández-Aroca, D. M., et al. "MAPK11 (p38β) is a major determinant of cellular radiosensitivity by controlling ionizing radiation-associated senescence: An in vitro study." Clinical and Translational Radiation Oncology (2023): 100649.
Pubmed: 37346275
DOI: 10.1016/j.ctro.2023.100649
Research Highlights
Rachwał, Kamila, et al. "Red Kale (Brassica oleracea L. ssp. acephala L. var. sabellica) Induces Apoptosis in Human Colorectal Cancer Cells In Vitro." Molecules 28.19 (2023): 6938.
This article presents the findings of research on the impact of consuming red kale (Brassica oleracea var. acephala) on blood lipid levels. The study aimed to understand how including red kale in the diet can affect lipid profiles. The data collected and analyzed showed a positive correlation between red kale intake and improvements in blood lipid levels. These results provide evidence for the potential health benefits of incorporating red kale into one's diet.
Rachwał, Kamila, et al. "Red Kale (Brassica oleracea L. ssp. acephala L. var. sabellica) Induces Apoptosis in Human Colorectal Cancer Cells In Vitro." Molecules 28.19 (2023): 6938.
Pubmed:
37836781
DOI:
10.3390/molecules28196938
Forghani-Ramandi, Mohammad-Moien. et al. "Illuminating HTLV 1-induced Adult T-cell Leukemia/Lymphoma transcriptomic signature: a systems virology approach." Virus research, 2023.
Adult T-cell leukemia/lymphoma (ATLL) is a challenging malignancy linked to human T-cell leukemia virus type 1 (HTLV-1) infection, characterized by poor patient prognosis due to limited understanding of its pathogenesis. The study systematically identified dysregulated genes and implicated pathways, including Apoptosis, HTLV-1 infection, and immune regulation. Notably, MAPK3, PIK3CD, KRAS, NFKB1, TNF, and other genes emerged as potential biomarkers. QRT-PCR confirmed the upregulation of ADCY1 and ADCY3. These findings spotlight the crucial role of specific pathways and genes in ATLL development, warranting further exploration for potential diagnostic and therapeutic applications.
Forghani-Ramandi, Mohammad-Moien. et al. "Illuminating HTLV 1-induced Adult T-cell Leukemia/Lymphoma transcriptomic signature: a systems virology approach." Virus research, 2023.
Pubmed:
37832654
DOI:
10.1016/j.virusres.2023.199237
